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dc.contributor.authorHale, R J
dc.contributor.authorRyder, W David J
dc.contributor.authorWilcox, F L
dc.contributor.authorBuckley, C H
dc.contributor.authorTindall, V R
dc.date.accessioned2010-08-11T16:24:05Z
dc.date.available2010-08-11T16:24:05Z
dc.date.issued1992-03
dc.identifier.citationCervical carcinoma: a hazard model in early stage disease. 1992, 2 (2):79-82 Int J Gynecol Canceren
dc.identifier.issn1525-1438
dc.identifier.pmid11576240
dc.identifier.doi10.1046/j.1525-1438.1992.02020079.x
dc.identifier.urihttp://hdl.handle.net/10541/109499
dc.description.abstractThe 235 patients with stage IB/IIA cervical carcinoma treated by Wertheim's hysterectomy, as a primary procedure, at St Mary's Hospital, Manchester between 1975 and 1989 inclusive, form the basis of this study. Using Cox's regression model, four variables were shown to have independent prognostic significance. These were: (1) lymphatic permeation (adjacent to the tumor); (2) tumor volume; (3) being pregnant at diagnosis and (4) lymph node metastases. A heuristic model was formulated which was based upon these four factors and by using this information it was possible to separate the patients into four distinct prognostic groups. It is suggested that this model may prove useful in identifying those patients at a higher risk of dying of disease and who would benefit from early adjuvant systemic therapy.
dc.languageENG
dc.language.isoenen
dc.subjectCervical Carcinomaen
dc.subjectHeuristic Modelen
dc.subjectPrognostic Factorsen
dc.titleCervical carcinoma: a hazard model in early stage disease.en
dc.typeArticleen
dc.contributor.departmentDepartment of Reproductive Pathology and the University Department of Obstetrics and Gynaecology, St Mary's Hospital, Manchester Department of Medical Statistics, Christie Hospital and Holt Radium Institute, Manchester Department of Obstetrics and Gynaecology, Royal Victoria Hospital, Blackpool.en
dc.identifier.journalInternational Journal of Gynecological Canceren
html.description.abstractThe 235 patients with stage IB/IIA cervical carcinoma treated by Wertheim's hysterectomy, as a primary procedure, at St Mary's Hospital, Manchester between 1975 and 1989 inclusive, form the basis of this study. Using Cox's regression model, four variables were shown to have independent prognostic significance. These were: (1) lymphatic permeation (adjacent to the tumor); (2) tumor volume; (3) being pregnant at diagnosis and (4) lymph node metastases. A heuristic model was formulated which was based upon these four factors and by using this information it was possible to separate the patients into four distinct prognostic groups. It is suggested that this model may prove useful in identifying those patients at a higher risk of dying of disease and who would benefit from early adjuvant systemic therapy.


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