AffiliationDepartment of Obstetrics and Gynaecology, St. Mary's Hospital, Manchester, UK.
MetadataShow full item record
AbstractOBJECTIVE: To investigate the impact of premature ovarian failure due to whole abdominal radiotherapy (DXT) in childhood on uterine physical characteristics and blood flow and measuring the uterine response to exogenous sex steroid replacement. DESIGN: A comparative observational study SUBJECTS: 10 women with premature ovarian failure due to treatment with whole abdominal irradiation in childhood. A comparison group of 22 women with premature ovarian failure who had not received whole abdominal DXT. MAIN OUTCOME MEASURES: Uterine length and uterine blood flow measurement plus serial assessment of endometrial thickness during a cycle of exogenous sex steroid replacement. RESULTS: Uterine length was significantly less (P less than 0.01) in women who had been exposed to whole abdominal DXT in childhood (mean 4.1 cm, 2SE 0.8) compared with a mean of 7.3 cm (2SE 0.6) in the comparison group. The three women in the DXT group who were studied serially had no increase in endometrial thickness in response to physiological sex steroid replacement therapy and most of the 10 irradiated women had no detectable uterine blood flow with Doppler ultrasound. CONCLUSIONS: Uterine musculature and blood flow are irreversibly affected by high dose irradiation in childhood. Non-invasive assessment of this nature may predict potential for pregnancy following ovum donation and embryo transfer.
CitationAbdominal irradiation in childhood; the potential for pregnancy. 1992, 99 (5):392-4 Br J Obstet Gynaecol
JournalBritish Journal of Obstetrics and Gynaecology
- Radiation damage to the uterus -- review of the effects of treatment of childhood cancer.
- Authors: Critchley HO, Bath LE, Wallace WH
- Issue date: 2002 May
- Factors of importance for implantation and problems after treatment for childhood cancer.
- Authors: Critchley HO
- Issue date: 1999 Jul
- Unanticipated pregnancy with intrauterine growth retardation after radiation-induced ovarian failure. A case report.
- Authors: Hammer RA, Urnes PD, Lurain JR
- Issue date: 1996 May
- Ovarian and uterine characteristics after total body irradiation in childhood and adolescence: response to sex steroid replacement.
- Authors: Bath LE, Critchley HO, Chambers SE, Anderson RA, Kelnar CJ, Wallace WH
- Issue date: 1999 Dec
- Successful pregnancies after combined pentoxifylline-tocopherol treatment in women with premature ovarian failure who are resistant to hormone replacement therapy.
- Authors: Letur-Konirsch H, Delanian S
- Issue date: 2003 Feb