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    Abdominal irradiation in childhood; the potential for pregnancy.

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    Authors
    Critchley, H O
    Wallace, W Hamish B
    Shalet, Stephen M
    Mamtora, H
    Higginson, J
    Anderson, D C
    Affiliation
    Department of Obstetrics and Gynaecology, St. Mary's Hospital, Manchester, UK.
    Issue Date
    1992-05
    
    Metadata
    Show full item record
    Abstract
    OBJECTIVE: To investigate the impact of premature ovarian failure due to whole abdominal radiotherapy (DXT) in childhood on uterine physical characteristics and blood flow and measuring the uterine response to exogenous sex steroid replacement. DESIGN: A comparative observational study SUBJECTS: 10 women with premature ovarian failure due to treatment with whole abdominal irradiation in childhood. A comparison group of 22 women with premature ovarian failure who had not received whole abdominal DXT. MAIN OUTCOME MEASURES: Uterine length and uterine blood flow measurement plus serial assessment of endometrial thickness during a cycle of exogenous sex steroid replacement. RESULTS: Uterine length was significantly less (P less than 0.01) in women who had been exposed to whole abdominal DXT in childhood (mean 4.1 cm, 2SE 0.8) compared with a mean of 7.3 cm (2SE 0.6) in the comparison group. The three women in the DXT group who were studied serially had no increase in endometrial thickness in response to physiological sex steroid replacement therapy and most of the 10 irradiated women had no detectable uterine blood flow with Doppler ultrasound. CONCLUSIONS: Uterine musculature and blood flow are irreversibly affected by high dose irradiation in childhood. Non-invasive assessment of this nature may predict potential for pregnancy following ovum donation and embryo transfer.
    Citation
    Abdominal irradiation in childhood; the potential for pregnancy. 1992, 99 (5):392-4 Br J Obstet Gynaecol
    Journal
    British Journal of Obstetrics and Gynaecology
    URI
    http://hdl.handle.net/10541/109491
    PubMed ID
    1622911
    Type
    Article
    Language
    en
    ISSN
    0306-5456
    Collections
    All Christie Publications

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