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dc.contributor.authorBirch, Jillian M
dc.contributor.authorBlair, Val
dc.date.accessioned2010-08-11T15:34:25Z
dc.date.available2010-08-11T15:34:25Z
dc.date.issued1992-08
dc.identifier.citationThe epidemiology of infant cancers. 1992, 18:S2-4 Br J Cancer Supplen
dc.identifier.issn0306-9443
dc.identifier.pmid1503921
dc.identifier.urihttp://hdl.handle.net/10541/109487
dc.description.abstractCancers in infants represent less than 0.05% of all malignant neoplasms, but form a particularly interesting group for study. The ratio of solid tumours to leukaemias is 2:1 in children aged 1-14 but 5:1 in infants less than 1 year. The rate for neuroblastoma which is the most common malignancy in infants is four times higher in children aged under 1 year than in 1-14 year olds. Other embryonal tumours, e.g. Wilms', heptablastoma and retinoblastoma also show higher rates in infants. The ratios of incidence in males to females differed in a number of instances in the two age groups, e.g. in leukaemias and liver tumours the male to female ratio is greater than one in 1-14 year old children but less than one in infants. These observations suggest that many infant tumours may be aetiologically distinct. Their early onset and predominantly embryonal nature suggest a pre-natal origin and genetic factors may be important.
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAdolescent
dc.subject.meshAge Factors
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshEngland
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshMale
dc.subject.meshNeoplasms
dc.subject.meshRegistries
dc.subject.meshSex Ratio
dc.titleThe epidemiology of infant cancers.en
dc.typeArticleen
dc.contributor.departmentCRC Paediatric Group, Christie Hospital & Holt Radium Institute, Manchester, UK.en
dc.identifier.journalThe British Journal of Cancer Supplementen
html.description.abstractCancers in infants represent less than 0.05% of all malignant neoplasms, but form a particularly interesting group for study. The ratio of solid tumours to leukaemias is 2:1 in children aged 1-14 but 5:1 in infants less than 1 year. The rate for neuroblastoma which is the most common malignancy in infants is four times higher in children aged under 1 year than in 1-14 year olds. Other embryonal tumours, e.g. Wilms', heptablastoma and retinoblastoma also show higher rates in infants. The ratios of incidence in males to females differed in a number of instances in the two age groups, e.g. in leukaemias and liver tumours the male to female ratio is greater than one in 1-14 year old children but less than one in infants. These observations suggest that many infant tumours may be aetiologically distinct. Their early onset and predominantly embryonal nature suggest a pre-natal origin and genetic factors may be important.


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