The epidemiology of infant cancers.
dc.contributor.author | Birch, Jillian M | |
dc.contributor.author | Blair, Val | |
dc.date.accessioned | 2010-08-11T15:34:25Z | |
dc.date.available | 2010-08-11T15:34:25Z | |
dc.date.issued | 1992-08 | |
dc.identifier.citation | The epidemiology of infant cancers. 1992, 18:S2-4 Br J Cancer Suppl | en |
dc.identifier.issn | 0306-9443 | |
dc.identifier.pmid | 1503921 | |
dc.identifier.uri | http://hdl.handle.net/10541/109487 | |
dc.description.abstract | Cancers in infants represent less than 0.05% of all malignant neoplasms, but form a particularly interesting group for study. The ratio of solid tumours to leukaemias is 2:1 in children aged 1-14 but 5:1 in infants less than 1 year. The rate for neuroblastoma which is the most common malignancy in infants is four times higher in children aged under 1 year than in 1-14 year olds. Other embryonal tumours, e.g. Wilms', heptablastoma and retinoblastoma also show higher rates in infants. The ratios of incidence in males to females differed in a number of instances in the two age groups, e.g. in leukaemias and liver tumours the male to female ratio is greater than one in 1-14 year old children but less than one in infants. These observations suggest that many infant tumours may be aetiologically distinct. Their early onset and predominantly embryonal nature suggest a pre-natal origin and genetic factors may be important. | |
dc.language.iso | en | en |
dc.subject | Cancer | en |
dc.subject.mesh | Adolescent | |
dc.subject.mesh | Age Factors | |
dc.subject.mesh | Child | |
dc.subject.mesh | Child, Preschool | |
dc.subject.mesh | England | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Infant | |
dc.subject.mesh | Male | |
dc.subject.mesh | Neoplasms | |
dc.subject.mesh | Registries | |
dc.subject.mesh | Sex Ratio | |
dc.title | The epidemiology of infant cancers. | en |
dc.type | Article | en |
dc.contributor.department | CRC Paediatric Group, Christie Hospital & Holt Radium Institute, Manchester, UK. | en |
dc.identifier.journal | The British Journal of Cancer Supplement | en |
html.description.abstract | Cancers in infants represent less than 0.05% of all malignant neoplasms, but form a particularly interesting group for study. The ratio of solid tumours to leukaemias is 2:1 in children aged 1-14 but 5:1 in infants less than 1 year. The rate for neuroblastoma which is the most common malignancy in infants is four times higher in children aged under 1 year than in 1-14 year olds. Other embryonal tumours, e.g. Wilms', heptablastoma and retinoblastoma also show higher rates in infants. The ratios of incidence in males to females differed in a number of instances in the two age groups, e.g. in leukaemias and liver tumours the male to female ratio is greater than one in 1-14 year old children but less than one in infants. These observations suggest that many infant tumours may be aetiologically distinct. Their early onset and predominantly embryonal nature suggest a pre-natal origin and genetic factors may be important. |