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dc.contributor.authorBanerjee, Saumitra S
dc.contributor.authorEyden, Brian P
dc.contributor.authorWells, S
dc.contributor.authorMcWilliam, L J
dc.contributor.authorHarris, Martin
dc.date.accessioned2010-08-11T15:26:00Z
dc.date.available2010-08-11T15:26:00Z
dc.date.issued1992-07
dc.identifier.citationPseudoangiosarcomatous carcinoma: a clinicopathological study of seven cases. 1992, 21 (1):13-23 Histopathologyen
dc.identifier.issn0309-0167
dc.identifier.pmid1634198
dc.identifier.doi10.1111/j.1365-2559.1992.tb00338.x
dc.identifier.urihttp://hdl.handle.net/10541/109486
dc.description.abstractSeven cases of carcinoma mimicking angiosarcoma occurring in skin (3 cases), breast (3) and lung (1) are described. The cutaneous, pulmonary and one of the breast carcinomas were poorly differentiated and squamous in type; the other two breast tumours were poorly differentiated ductal carcinomas with focal squamous differentiation. Histologically, the pseudoangiosarcomatous pattern was due to complex anastomosing channels and spaces lined by neoplastic cells. The spaces contained hyaluronic acid. The neoplastic cells exhibited cytokeratin positivity but yielded negative results with the endothelial cell markers, factor VIII-related antigen and CD 34 (QB-END/10). Two breast tumours showed binding of UEA-1. Ultrastructurally, unequivocal epithelial differentiation was demonstrated in six of the cases. Pathogenetically, these tumours appeared to be variants of acantholytic squamous cell carcinoma. Recognition of this unusual form of carcinoma is important, as an incorrect diagnosis of angiosarcoma may lead to inappropriate treatment and prognostication.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectLung Canceren
dc.subjectSkin Canceren
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshBreast Neoplasms
dc.subject.meshDiagnosis, Differential
dc.subject.meshFemale
dc.subject.meshHemangiosarcoma
dc.subject.meshHistocytochemistry
dc.subject.meshHumans
dc.subject.meshImmunoenzyme Techniques
dc.subject.meshLung Neoplasms
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshSkin Neoplasms
dc.titlePseudoangiosarcomatous carcinoma: a clinicopathological study of seven cases.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalHistopathologyen
html.description.abstractSeven cases of carcinoma mimicking angiosarcoma occurring in skin (3 cases), breast (3) and lung (1) are described. The cutaneous, pulmonary and one of the breast carcinomas were poorly differentiated and squamous in type; the other two breast tumours were poorly differentiated ductal carcinomas with focal squamous differentiation. Histologically, the pseudoangiosarcomatous pattern was due to complex anastomosing channels and spaces lined by neoplastic cells. The spaces contained hyaluronic acid. The neoplastic cells exhibited cytokeratin positivity but yielded negative results with the endothelial cell markers, factor VIII-related antigen and CD 34 (QB-END/10). Two breast tumours showed binding of UEA-1. Ultrastructurally, unequivocal epithelial differentiation was demonstrated in six of the cases. Pathogenetically, these tumours appeared to be variants of acantholytic squamous cell carcinoma. Recognition of this unusual form of carcinoma is important, as an incorrect diagnosis of angiosarcoma may lead to inappropriate treatment and prognostication.


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