Show simple item record

dc.contributor.authorSattar, A
dc.contributor.authorKumar, Shant
dc.contributor.authorWest, David C
dc.date.accessioned2010-08-11T14:37:00Z
dc.date.available2010-08-11T14:37:00Z
dc.date.issued1992-08
dc.identifier.citationDoes hyaluronan have a role in endothelial cell proliferation of the synovium? 1992, 22 (1):37-43 Semin. Arthritis Rheumen
dc.identifier.issn0049-0172
dc.identifier.pmid1384133
dc.identifier.doi10.1016/0049-0172(92)90047-H
dc.identifier.urihttp://hdl.handle.net/10541/109484
dc.description.abstractHyaluranate (HA) is a major constituent of synovial fluid, but its concentration and molecular size differ in normal and inflamed joints. HA can induce or inhibit angiogenesis depending on both its size and its concentration. Endothelial-cell endocytose-labeled macromolecular HA and HA oligosaccharides and binding studies have identified an HA-specific receptor on the endothelial cell surface (KD, 10(-10) mol/L; approximately 2,000/cell). The molecular weight of HA-binding proteins was found to be 90 to 125, 78, and 46 kd.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshAntigens, CD44
dc.subject.meshAorta
dc.subject.meshCell Division
dc.subject.meshCell Movement
dc.subject.meshCells, Cultured
dc.subject.meshCerebrovascular Circulation
dc.subject.meshEndothelium, Vascular
dc.subject.meshHyaluronic Acid
dc.subject.meshReceptors, Cell Surface
dc.subject.meshSynovial Membrane
dc.titleDoes hyaluronan have a role in endothelial cell proliferation of the synovium?en
dc.typeArticleen
dc.contributor.departmentClinical Research Laboratories, Christie Hospital and Holt Radium Institute, Manchester, England.en
dc.identifier.journalSeminars in Arthritis and Rheumatismen
html.description.abstractHyaluranate (HA) is a major constituent of synovial fluid, but its concentration and molecular size differ in normal and inflamed joints. HA can induce or inhibit angiogenesis depending on both its size and its concentration. Endothelial-cell endocytose-labeled macromolecular HA and HA oligosaccharides and binding studies have identified an HA-specific receptor on the endothelial cell surface (KD, 10(-10) mol/L; approximately 2,000/cell). The molecular weight of HA-binding proteins was found to be 90 to 125, 78, and 46 kd.


Files in this item

This item appears in the following Collection(s)

Show simple item record