Does hyaluronan have a role in endothelial cell proliferation of the synovium?
Affiliation
Clinical Research Laboratories, Christie Hospital and Holt Radium Institute, Manchester, England.Issue Date
1992-08
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Hyaluranate (HA) is a major constituent of synovial fluid, but its concentration and molecular size differ in normal and inflamed joints. HA can induce or inhibit angiogenesis depending on both its size and its concentration. Endothelial-cell endocytose-labeled macromolecular HA and HA oligosaccharides and binding studies have identified an HA-specific receptor on the endothelial cell surface (KD, 10(-10) mol/L; approximately 2,000/cell). The molecular weight of HA-binding proteins was found to be 90 to 125, 78, and 46 kd.Citation
Does hyaluronan have a role in endothelial cell proliferation of the synovium? 1992, 22 (1):37-43 Semin. Arthritis RheumJournal
Seminars in Arthritis and RheumatismDOI
10.1016/0049-0172(92)90047-HPubMed ID
1384133Type
ArticleLanguage
enISSN
0049-0172ae974a485f413a2113503eed53cd6c53
10.1016/0049-0172(92)90047-H
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