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    Does hyaluronan have a role in endothelial cell proliferation of the synovium?

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    Authors
    Sattar, A
    Kumar, Shant
    West, David C
    Affiliation
    Clinical Research Laboratories, Christie Hospital and Holt Radium Institute, Manchester, England.
    Issue Date
    1992-08
    
    Metadata
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    Abstract
    Hyaluranate (HA) is a major constituent of synovial fluid, but its concentration and molecular size differ in normal and inflamed joints. HA can induce or inhibit angiogenesis depending on both its size and its concentration. Endothelial-cell endocytose-labeled macromolecular HA and HA oligosaccharides and binding studies have identified an HA-specific receptor on the endothelial cell surface (KD, 10(-10) mol/L; approximately 2,000/cell). The molecular weight of HA-binding proteins was found to be 90 to 125, 78, and 46 kd.
    Citation
    Does hyaluronan have a role in endothelial cell proliferation of the synovium? 1992, 22 (1):37-43 Semin. Arthritis Rheum
    Journal
    Seminars in Arthritis and Rheumatism
    URI
    http://hdl.handle.net/10541/109484
    DOI
    10.1016/0049-0172(92)90047-H
    PubMed ID
    1384133
    Type
    Article
    Language
    en
    ISSN
    0049-0172
    ae974a485f413a2113503eed53cd6c53
    10.1016/0049-0172(92)90047-H
    Scopus Count
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