Does hyaluronan have a role in endothelial cell proliferation of the synovium?
AffiliationClinical Research Laboratories, Christie Hospital and Holt Radium Institute, Manchester, England.
MetadataShow full item record
AbstractHyaluranate (HA) is a major constituent of synovial fluid, but its concentration and molecular size differ in normal and inflamed joints. HA can induce or inhibit angiogenesis depending on both its size and its concentration. Endothelial-cell endocytose-labeled macromolecular HA and HA oligosaccharides and binding studies have identified an HA-specific receptor on the endothelial cell surface (KD, 10(-10) mol/L; approximately 2,000/cell). The molecular weight of HA-binding proteins was found to be 90 to 125, 78, and 46 kd.
CitationDoes hyaluronan have a role in endothelial cell proliferation of the synovium? 1992, 22 (1):37-43 Semin. Arthritis Rheum
JournalSeminars in Arthritis and Rheumatism
- The effect of hyaluronate and its oligosaccharides on endothelial cell proliferation and monolayer integrity.
- Authors: West DC, Kumar S
- Issue date: 1989 Jul
- Hyaluronan-binding protein in endothelial cell morphogenesis.
- Authors: Banerjee SD, Toole BP
- Issue date: 1992 Nov
- Hyaluronan oligosaccharides are potential stimulators to angiogenesis via RHAMM mediated signal pathway in wound healing.
- Authors: Gao F, Yang CX, Mo W, Liu YW, He YQ
- Issue date: 2008
- Angiogenic oligosaccharides of hyaluronan induce protein tyrosine kinase activity in endothelial cells and activate a cytoplasmic signal transduction pathway resulting in proliferation.
- Authors: Slevin M, Krupinski J, Kumar S, Gaffney J
- Issue date: 1998 Aug
- Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses.
- Authors: Slevin M, Kumar S, Gaffney J
- Issue date: 2002 Oct 25