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    The Christie Hospital adjuvant tamoxifen trial.

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    Authors
    Ribeiro, G
    Swindell, Ric
    Affiliation
    Department of Radiotherapy, Christie Hospital, Holt Radium Institute, Manchester, England.
    Issue Date
    1992
    
    Metadata
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    Abstract
    A clinical trial was carried out at The Christie Hospital, Manchester, England, between November 1976 and June 1982. Following surgery, patients with clinical stage T1-T3a, N1-N2b, M0 tumors were randomly allocated in the following way: premenopausal women to either tamoxifen 20 mg/day for 1 year or to an irradiation-induced menopause; postmenopausal women to either tamoxifen for 1 year or no further treatment (controls). In the node-negative subgroup, an analysis at a median follow-up of 10 years shows no statistically significant difference in overall or disease-free survival between tamoxifen-treated patients and irradiation-induced menopause and control patients. Side effects were few, and compliance was excellent. There was no significant increase of second primary tumors in target endocrine organs in the tamoxifen-treated patients. For the whole series of 961 patients, a log-rank analysis of events, allowing for node status, still shows a statistically significant benefit for tamoxifen-treated patients (P = .04).
    Citation
    The Christie Hospital adjuvant tamoxifen trial. 1992 (11):121-5 J. Natl. Cancer Inst Monographs
    Journal
    Journal of the National Cancer Institute Monographs
    URI
    http://hdl.handle.net/10541/109472
    PubMed ID
    1627418
    Type
    Article
    Language
    en
    ISSN
    1052-6773
    Collections
    All Christie Publications

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