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dc.contributor.authorZanella, Fabian
dc.contributor.authorLink, Wolfgang
dc.contributor.authorCarnero, Amancio
dc.date.accessioned2010-08-10T15:45:05Z
dc.date.available2010-08-10T15:45:05Z
dc.date.issued2010-03-01
dc.identifier.citationUnderstanding FOXO, new views on old transcription factors. 2010, 10 (2):135-46 Curr Cancer Drug Targetsen
dc.identifier.issn1873-5576
dc.identifier.pmid20088800
dc.identifier.urihttp://hdl.handle.net/10541/109434
dc.description.abstractFOXO proteins are evolutionarily conserved transcription factors implicated in several fundamental cellular processes, functioning as end-point for transcriptional programs involved in apoptosis, stress response and longevity. Abrogation of FOXO function is very frequent in human cancer, therefore the mechanisms of regulation of the FOXO proteins are receiving increasing attention in cancer research. The FOXO proteins integrate regulatory inputs from a variety of upstream signaling pathways, most importantly in response to growth factor and stress signalling. Recently, FOXO factors have been established as tumor suppressors, promoting the transcription of pro-apoptotic molecules like FasL and Bim when the PI3K/Akt pathway is downregulated due to nutrient or serum starvation and cellular stress. Therefore, understanding the modulation of FOXO transcription factors will allow the design of new compounds with antitumor potential.
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAging
dc.subject.meshAnimals
dc.subject.meshApoptosis
dc.subject.meshCell Cycle
dc.subject.meshForkhead Transcription Factors
dc.subject.meshHumans
dc.subject.meshNeoplasms
dc.subject.meshOxidative Stress
dc.subject.meshSignal Transduction
dc.subject.meshTranscription Factors
dc.titleUnderstanding FOXO, new views on old transcription factors.en
dc.typeArticleen
dc.contributor.departmentExperimental Therapeutics programme, Spanish National Cancer Research Centre, Madrid, Spain.en
dc.identifier.journalCurrent Cancer Drug Targetsen
html.description.abstractFOXO proteins are evolutionarily conserved transcription factors implicated in several fundamental cellular processes, functioning as end-point for transcriptional programs involved in apoptosis, stress response and longevity. Abrogation of FOXO function is very frequent in human cancer, therefore the mechanisms of regulation of the FOXO proteins are receiving increasing attention in cancer research. The FOXO proteins integrate regulatory inputs from a variety of upstream signaling pathways, most importantly in response to growth factor and stress signalling. Recently, FOXO factors have been established as tumor suppressors, promoting the transcription of pro-apoptotic molecules like FasL and Bim when the PI3K/Akt pathway is downregulated due to nutrient or serum starvation and cellular stress. Therefore, understanding the modulation of FOXO transcription factors will allow the design of new compounds with antitumor potential.


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