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    Understanding FOXO, new views on old transcription factors.

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    Authors
    Zanella, Fabian
    Link, Wolfgang
    Carnero, Amancio
    Affiliation
    Experimental Therapeutics programme, Spanish National Cancer Research Centre, Madrid, Spain.
    Issue Date
    2010-03-01
    
    Metadata
    Show full item record
    Abstract
    FOXO proteins are evolutionarily conserved transcription factors implicated in several fundamental cellular processes, functioning as end-point for transcriptional programs involved in apoptosis, stress response and longevity. Abrogation of FOXO function is very frequent in human cancer, therefore the mechanisms of regulation of the FOXO proteins are receiving increasing attention in cancer research. The FOXO proteins integrate regulatory inputs from a variety of upstream signaling pathways, most importantly in response to growth factor and stress signalling. Recently, FOXO factors have been established as tumor suppressors, promoting the transcription of pro-apoptotic molecules like FasL and Bim when the PI3K/Akt pathway is downregulated due to nutrient or serum starvation and cellular stress. Therefore, understanding the modulation of FOXO transcription factors will allow the design of new compounds with antitumor potential.
    Citation
    Understanding FOXO, new views on old transcription factors. 2010, 10 (2):135-46 Curr Cancer Drug Targets
    Journal
    Current Cancer Drug Targets
    URI
    http://hdl.handle.net/10541/109434
    PubMed ID
    20088800
    Type
    Article
    Language
    en
    ISSN
    1873-5576
    Collections
    All Paterson Institute for Cancer Research

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