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    How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

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    Authors
    Labib, Karim
    Affiliation
    Cancer Research UK, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, United Kingdom. klabib@picr.man.ac.uk
    Issue Date
    2010-06-15
    
    Metadata
    Show full item record
    Abstract
    Chromosome replication occurs precisely once during the cell cycle of almost all eukaryotic cells, and is a highly complex process that is still understood relatively poorly. Two conserved kinases called Cdc7 (cell division cycle 7) and cyclin-dependent kinase (CDK) are required to establish replication forks during the initiation of chromosome replication, and a key feature of this process is the activation of the replicative DNA helicase in situ at each origin of DNA replication. A series of recent studies has shed new light on the targets of Cdc7 and CDK, indicating that chromosome replication probably initiates by a fundamentally similar mechanism in all eukaryotes.
    Citation
    How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells? 2010, 24 (12):1208-19 Genes Dev
    Journal
    Genes & Development
    URI
    http://hdl.handle.net/10541/109425
    DOI
    10.1101/gad.1933010
    PubMed ID
    20551170
    Type
    Article
    Language
    en
    ISSN
    1549-5477
    ae974a485f413a2113503eed53cd6c53
    10.1101/gad.1933010
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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