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    Different roles of radical scavengers--ascorbate and urate in the cerebrospinal fluid of amyotrophic lateral sclerosis patients.

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    Authors
    Spasojević, Ivan
    Stević, Zorica
    Nikolić-Kokić, Aleksandra
    Jones, David R
    Blagojević, Dusko
    Spasić, Mihajlo B
    Affiliation
    Institute for Multidisciplinary Research, University of Belgrade, Kneza Viseslava 1, 11000 Belgrade, Serbia. ivan@cms.bg.ac.rs
    Issue Date
    2010
    
    Metadata
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    Abstract
    Ferrous iron, released from iron deposits in the motor cortex and other brain regions of amyotrophic lateral sclerosis (ALS) patients, participates in the Fenton reaction in cerebrospinal fluid (CSF) alongside H(2)O(2), which is continuously released by neuronal cells. In vivo, the production of notoriously reactive hydroxyl radicals via this reaction could lead to the progression of the disease. Herein, we have examined the effect of ascorbate and uric acid on the production of hydroxyl radicals in CSF from both sporadic ALS patients and control subjects. Electron paramagnetic resonance spectroscopy identified ascorbyl radicals in CSF from ALS patients whereas it was undetectable in control CSF. The addition of H(2)O(2) to the CSF from ALS patients provoked further formation of ascorbyl radicals and the formation of hydroxyl radicals ex vivo. The hydroxyl addition of uric acid to CSF from ALS patients diminished the production of hydroxyl radicals. In conclusion, there are clear differences between the roles of the two examined radical scavengers in the CSF of ALS patients indicating that the use of ascorbate could have unfavourable effects in ALS patients.
    Citation
    Different roles of radical scavengers--ascorbate and urate in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. 2010, 15 (2):81-6 Redox Rep
    Journal
    Redox Report
    URI
    http://hdl.handle.net/10541/109419
    DOI
    10.1179/174329210X12650506623320
    PubMed ID
    20500989
    Type
    Article
    Language
    en
    ISSN
    1743-2928
    ae974a485f413a2113503eed53cd6c53
    10.1179/174329210X12650506623320
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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