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    Bioavailability and catalytic properties of copper and iron for Fenton chemistry in human cerebrospinal fluid.

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    Authors
    Spasojević, Ivan
    Mojović, Milos
    Stević, Zorica
    Spasić, Snezana D
    Jones, David R
    Morina, Arian
    Spasić, Mihajlo B
    Affiliation
    Institute for Multidisciplinary Research, University of Belgrade, 11000 Belgrade, Serbia. ivan@cms.bg.ac.rs
    Issue Date
    2010
    
    Metadata
    Show full item record
    Abstract
    A breakdown in homeostasis of redox-active metals represents an important factor for neurodegeneration. We have used EPR spectroscopy and BMPO spin-trap to investigate the catalytic properties and ligand modulation of redox activity of copper and iron in human cerebrospinal fluid (CSF). In contrast to iron, copper supplementation provoked a statistically significant increase in hydroxyl free radical generation in CSF treated with H(2)O(2). However, in a binary copper/iron containing Fenton system, iron catalytically activated copper. The chelator EDTA, which represents a model of physiological metal ligands, completely prevented copper's redox activity in CSF, while iron chelation led to a significant increase in hydroxyl radical generation, indicating that copper and iron do not only have diverse catalytic properties in the CSF but also that their redox activities are differently modulated by ligands. The application of DDC reduced hydroxyl radical generation in the CSF containing catalytically active metals (free Cu(2+) or Fe(3+)-EDTA complex). We conclude that chelators, such as DDC, are capable of preventing the prooxidative activity of both metals and may be suitable for reducing hydroxyl radical formation in certain pathophysiological settings.
    Citation
    Bioavailability and catalytic properties of copper and iron for Fenton chemistry in human cerebrospinal fluid. 2010, 15 (1):29-35 Redox Rep
    Journal
    Redox Report
    URI
    http://hdl.handle.net/10541/109406
    DOI
    10.1179/174329210X12650506623087
    PubMed ID
    20196926
    Type
    Article
    Language
    en
    ISSN
    1743-2928
    ae974a485f413a2113503eed53cd6c53
    10.1179/174329210X12650506623087
    Scopus Count
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    All Paterson Institute for Cancer Research

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