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    Irradiated Blm-deficient mice are a highly tumor prone model for analysis of a broad spectrum of hematologic malignancies.

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    Authors
    Warren, Madhuri
    Chung, Yeun-Jun
    Howat, William J
    Harrison, Hannah
    McGinnis, Ralph
    Hao, Xingpei
    McCafferty, John
    Fredrickson, Torgny N
    Bradley, Allan
    Morse, Herbert C
    Affiliation
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. mvw@pathologydiagnostics.com
    Issue Date
    2010-02
    
    Metadata
    Show full item record
    Abstract
    Mutations in the BLM gene cause human Bloom syndrome (BS), an autosomal recessive disorder of growth retardation, immunodeficiency and cancer predisposition. Homozygous null Blm(m3/m3) mice are cancer prone with a 5-fold increased risk of cancer compared with Blm(m3/+) and Blm(+/+) mice. Irradiation of Blm(m3/m3) mice increased the risk to 28-fold. Tumors occurred mainly in the hematopoietic system and were similar to those in BS based on detailed histologic and immunohistochemical analyses. Irradiated Blm-deficient mice thus provide a novel model for understanding accelerated malignancies in BS and a new platform for investigating the molecular basis for a wide range of hematopoietic neoplasms.
    Citation
    Irradiated Blm-deficient mice are a highly tumor prone model for analysis of a broad spectrum of hematologic malignancies. 2010, 34 (2):210-20 Leuk Res
    Journal
    Leukemia Research
    URI
    http://hdl.handle.net/10541/109391
    DOI
    10.1016/j.leukres.2009.06.007
    PubMed ID
    19709744
    Type
    Article
    Language
    en
    ISSN
    1873-5835
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.leukres.2009.06.007
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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