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    Biological mechanisms linking obesity and cancer risk: new perspectives.

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    Authors
    Roberts, Darren L
    Dive, Caroline
    Renehan, Andrew G
    Affiliation
    Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, The Christie NHS Foundation Trust, Manchester, UK.
    Issue Date
    2010
    
    Metadata
    Show full item record
    Abstract
    Body mass index, as an approximation of body adiposity, is associated with increased risk of several common and less common malignancies in a sex- and site-specific manner. These findings implicate sex- and cancer site-specific biological mechanisms underpinning these associations, and it is unlikely that there is a "one system fits all" mechanism. Three main candidate systems have been proposed-insulin and the insulin-like growth factor-I axis, sex steroids, and adipokines-but there are shortfalls to these hypotheses. In this review, three novel candidate mechanisms are proposed: obesity-induced hypoxia, shared genetic susceptibility, and migrating adipose stromal cells. While public health policies aimed at curbing the underlying causes of the obesity epidemic are being implemented, there is a parallel need to better understand the biological processes linking obesity and cancer as a prerequisite to the development of new approaches to prevention and treatment.
    Citation
    Biological mechanisms linking obesity and cancer risk: new perspectives. 2010, 61:301-16 Annu. Rev. Med.
    Journal
    Annual Review of Medicine
    URI
    http://hdl.handle.net/10541/109346
    DOI
    10.1146/annurev.med.080708.082713
    PubMed ID
    19824817
    Type
    Article
    Language
    en
    ISSN
    1545-326X
    ae974a485f413a2113503eed53cd6c53
    10.1146/annurev.med.080708.082713
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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