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dc.contributor.authorShimoda, Masayukien
dc.contributor.authorMellody, Kieran Ten
dc.contributor.authorOrimo, Akiraen
dc.date.accessioned2010-08-09T15:44:39Z
dc.date.available2010-08-09T15:44:39Z
dc.date.issued2010-02
dc.identifier.citationCarcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression. 2010, 21 (1):19-25 Semin. Cell Dev. Biol.en
dc.identifier.issn1096-3634
dc.identifier.pmid19857592
dc.identifier.doi10.1016/j.semcdb.2009.10.002
dc.identifier.urihttp://hdl.handle.net/10541/109342
dc.description.abstractTumours are highly complex tissues composed of carcinoma cells and surrounding stroma, which is constructed by various different types of mesenchymal cells and an extracellular matrix (ECM). Carcinoma-associated fibroblasts (CAFs), which consist of both fibroblasts and myofibroblasts, are frequently observed in the stroma of human carcinomas, and their presence in large numbers is often associated with the development of high-grade malignancies and poor prognoses. Moreover, in human tumour xenograft models, CAFs extracted from the tumour are more capable of promoting tumour growth through their interactions with carcinoma cells when compared to those isolated from non-cancerous stroma. Taken together, these observations strongly suggest that CAFs actively contribute to tumour progression. In this review we highlight the emerging roles of these cells in promoting tumourigenesis, and we discuss the molecular mechanisms underlying their tumour-promoting capabilities and their cellular origin.
dc.language.isoenen
dc.subjectCanceren
dc.subjectCanerous Cell Transformationen
dc.subjectCancer Transplantationen
dc.subject.meshAnimals
dc.subject.meshCarcinoma
dc.subject.meshCell Transformation, Neoplastic
dc.subject.meshDisease Progression
dc.subject.meshEpigenesis, Genetic
dc.subject.meshFibroblasts
dc.subject.meshHumans
dc.subject.meshNeoplasm Transplantation
dc.subject.meshNeoplasms
dc.subject.meshTransplantation, Heterologous
dc.titleCarcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.en
dc.identifier.journalSeminars in Cell & Developmental Biologyen
html.description.abstractTumours are highly complex tissues composed of carcinoma cells and surrounding stroma, which is constructed by various different types of mesenchymal cells and an extracellular matrix (ECM). Carcinoma-associated fibroblasts (CAFs), which consist of both fibroblasts and myofibroblasts, are frequently observed in the stroma of human carcinomas, and their presence in large numbers is often associated with the development of high-grade malignancies and poor prognoses. Moreover, in human tumour xenograft models, CAFs extracted from the tumour are more capable of promoting tumour growth through their interactions with carcinoma cells when compared to those isolated from non-cancerous stroma. Taken together, these observations strongly suggest that CAFs actively contribute to tumour progression. In this review we highlight the emerging roles of these cells in promoting tumourigenesis, and we discuss the molecular mechanisms underlying their tumour-promoting capabilities and their cellular origin.


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