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    Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression.

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    Authors
    Shimoda, Masayuki
    Mellody, Kieran T
    Orimo, Akira
    Affiliation
    Department of Pathology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
    Issue Date
    2010-02
    
    Metadata
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    Abstract
    Tumours are highly complex tissues composed of carcinoma cells and surrounding stroma, which is constructed by various different types of mesenchymal cells and an extracellular matrix (ECM). Carcinoma-associated fibroblasts (CAFs), which consist of both fibroblasts and myofibroblasts, are frequently observed in the stroma of human carcinomas, and their presence in large numbers is often associated with the development of high-grade malignancies and poor prognoses. Moreover, in human tumour xenograft models, CAFs extracted from the tumour are more capable of promoting tumour growth through their interactions with carcinoma cells when compared to those isolated from non-cancerous stroma. Taken together, these observations strongly suggest that CAFs actively contribute to tumour progression. In this review we highlight the emerging roles of these cells in promoting tumourigenesis, and we discuss the molecular mechanisms underlying their tumour-promoting capabilities and their cellular origin.
    Citation
    Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression. 2010, 21 (1):19-25 Semin. Cell Dev. Biol.
    Journal
    Seminars in Cell & Developmental Biology
    URI
    http://hdl.handle.net/10541/109342
    DOI
    10.1016/j.semcdb.2009.10.002
    PubMed ID
    19857592
    Type
    Article
    Language
    en
    ISSN
    1096-3634
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.semcdb.2009.10.002
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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