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    Blood cell generation from the hemangioblast.

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    Authors
    Lancrin, Christophe
    Sroczynska, Patrycja
    Serrano, Alicia G
    Gandillet, Arnaud
    Ferreras, Cristina
    Kouskoff, Valerie
    Lacaud, Georges
    Affiliation
    Cancer Research UK, Stem Cell Biology Group, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK.
    Issue Date
    2010-02
    
    Metadata
    Show full item record
    Abstract
    Understanding how blood cells are generated is important from a biological perspective but also has potential implications in the treatment of blood diseases. Such knowledge could potentially lead to defining new conditions to amplify hematopoietic stem cells (HSCs) or could translate into new methods to produce HSCs, or other types of blood cells, from human embryonic stem cells or induced pluripotent stem cells. Additionally, as most key transcription factors regulating early hematopoietic development have also been implicated in various types of leukemia, understanding their function during normal development could result in a better comprehension of their roles during abnormal hematopoiesis in leukemia. In this review, we discuss our current understanding of the molecular and cellular mechanisms of blood development from the earliest hematopoietic precursor, the hemangioblast, a precursor for both endothelial and hematopoietic cell lineages.
    Citation
    Blood cell generation from the hemangioblast. 2010, 88 (2):167-72 J. Mol. Med.
    Journal
    Journal of Molecular Medicine
    URI
    http://hdl.handle.net/10541/109337
    DOI
    10.1007/s00109-009-0554-0
    PubMed ID
    19856139
    Type
    Article
    Language
    en
    ISSN
    1432-1440
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00109-009-0554-0
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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