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    T cell-based immunotherapy of metastatic renal cell carcinoma: modest success and future perspective.

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    Authors
    Shablak, Alaaeldin
    Hawkins, Robert E
    Rothwell, Dominic G
    Elkord, Eyad
    Affiliation
    Department of Medical Oncology, School of Cancer, Enabling Sciences and Technology, The University of Manchester, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Manchester, United Kingdom.
    Issue Date
    2009-11-01
    
    Metadata
    Show full item record
    Abstract
    Metastatic renal cell carcinoma (MRCC) remains a challenging malignancy to treat. Cancer immunotherapies have been extensively explored in melanoma and RCC as they poorly respond to conventional cytotoxic agents but show responses to a variety of immunologic agents. The recent considerable success of T cell-based immunotherapy in melanoma warrants further efforts to apply this treatment to other cancers including MRCC. Although RCC is an immunosensitive cancer, similar attempts in MRCC have shown a very limited success. In this review, we summarize the clinical data on T cell-based immunotherapies for MRCC showing the modest success that has been achieved to date. More importantly, we discuss potential strategies for improving its efficacy for the treatment of MRCC in light of the important achievements for treating metastatic melanoma. In particular, the growing evidence of success by combining expanded tumor-infiltrating lymphocytes with lymphodepletion merits investigation in MRCC. Identifying new RCC-associated antigens, optimized methods, and conditions for detection, isolation, and/or modification and expansion of tumor-specific T cells are all important strategies to be pursued for improving T cell-based immunotherapy of MRCC.
    Citation
    T cell-based immunotherapy of metastatic renal cell carcinoma: modest success and future perspective. 2009, 15 (21):6503-10 Clin. Cancer Res.
    Journal
    Clinical Cancer Research
    URI
    http://hdl.handle.net/10541/109332
    DOI
    10.1158/1078-0432.CCR-09-1605
    PubMed ID
    19843660
    Type
    Article
    Language
    en
    ISSN
    1078-0432
    ae974a485f413a2113503eed53cd6c53
    10.1158/1078-0432.CCR-09-1605
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research
    Medical Oncology

    entitlement

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