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    Antimigratory and antimetastatic effect of heparin-derived 4-18 unit oligosaccharides in a preclinical human melanoma metastasis model.

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    Authors
    Kenessey, István
    Simon, Erika
    Futosi, Krisztina
    Bereczky, Bíborka
    Kiss, Andrea
    Erdödi, Ferenc
    Gallagher, John T
    Tímár, József
    Tóvári, József
    Affiliation
    Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary.
    Issue Date
    2009-12
    
    Metadata
    Show full item record
    Abstract
    Heparin and its derivatives have been shown to inhibit angiogenesis and metastasis formation. Accordingly, we investigated the effect of heparin fragments containing 4 to 22 monomers on human melanoma cell proliferation, migration and invasion in vitro as well as on the in vivo metastatic potential in a SCID mouse model. Only oligosaccharide dp18 had significant inhibitory effect on cell proliferation. In contrast, cell migration was inhibited by all oligosaccharides studied except dp8 and dp22. Anti-CD44v3 antibody stimulated cell migration and invasion, and this effect could be attenuated by oligosaccharides dp4 and dp18. These fragments also inhibited the catalytic activity of myosin light chain phosphatase as well. Moreover, oligosaccharides dp4 and dp18 reduced the number of lung colonies formed in SCID mice intravenously injected with human melanoma cells, while dp22 proved to be ineffective in this respect. These studies revealed that fragments of heparin have an antimigratory and antimetastatic potential. These fragments lack the haemostatic effect of heparin, suggesting that they are potential specific antimetastatic agents in anticancer therapy.
    Citation
    Antimigratory and antimetastatic effect of heparin-derived 4-18 unit oligosaccharides in a preclinical human melanoma metastasis model. 2009, 102 (6):1265-73 Thromb. Haemost.
    Journal
    Thrombosis and Haemostasis
    URI
    http://hdl.handle.net/10541/109309
    DOI
    10.1160/TH09-01-0059
    PubMed ID
    19967160
    Type
    Article
    Language
    en
    ISSN
    0340-6245
    ae974a485f413a2113503eed53cd6c53
    10.1160/TH09-01-0059
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research
    School of Cancer and Imaging Sciences

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