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dc.contributor.authorVan den Bout, Imanen
dc.contributor.authorDivecha, Nullinen
dc.date.accessioned2010-08-09T15:29:31Z
dc.date.available2010-08-09T15:29:31Z
dc.date.issued2009-11-01
dc.identifier.citationPIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions. 2009, 122 (Pt 21):3837-50 J. Cell. Sci.en
dc.identifier.issn1477-9137
dc.identifier.pmid19889969
dc.identifier.doi10.1242/jcs.056127
dc.identifier.urihttp://hdl.handle.net/10541/109306
dc.description.abstractIt has long been known that phosphoinositides are present in cellular membranes, but only in the past four decades has our understanding of their importance for proper cell function advanced significantly. Key to determining the biological roles of phosphoinositides is understanding the enzymes involved in their metabolism. Although many such enzymes have now been identified, there is still much to learn about their cellular functions. Phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) are a group of kinases that catalyse the production of phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P(2)]. As well as being a substrate for the enzymes phospholipase C (PLC) and phosphatidylinositol 3-kinase (PI3K), PtdIns(4,5)P(2) acts as a second messenger in its own right, influencing a variety of cellular processes. In this Commentary, we review how PIP5Ks are modulated to achieve regulated PtdIns(4,5)P(2) production, and discuss the role of these proteins in different cellular processes.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshGene Expression Regulation, Enzymologic
dc.subject.meshHumans
dc.subject.meshMultigene Family
dc.subject.meshPhosphatidylinositol 4,5-Diphosphate
dc.subject.meshPhosphotransferases (Alcohol Group Acceptor)
dc.titlePIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.en
dc.typeArticleen
dc.contributor.departmentInositide Laboratory, Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, UK. ivbout@picr.man.ac.uken
dc.identifier.journalJournal of Cell Scienceen
html.description.abstractIt has long been known that phosphoinositides are present in cellular membranes, but only in the past four decades has our understanding of their importance for proper cell function advanced significantly. Key to determining the biological roles of phosphoinositides is understanding the enzymes involved in their metabolism. Although many such enzymes have now been identified, there is still much to learn about their cellular functions. Phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) are a group of kinases that catalyse the production of phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P(2)]. As well as being a substrate for the enzymes phospholipase C (PLC) and phosphatidylinositol 3-kinase (PI3K), PtdIns(4,5)P(2) acts as a second messenger in its own right, influencing a variety of cellular processes. In this Commentary, we review how PIP5Ks are modulated to achieve regulated PtdIns(4,5)P(2) production, and discuss the role of these proteins in different cellular processes.


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