Show simple item record

dc.contributor.authorPettit, George R
dc.contributor.authorMinardi, Mathew D
dc.contributor.authorHogan, Fiona
dc.contributor.authorPrice, Patricia M
dc.date.accessioned2010-08-09T13:08:40Z
dc.date.available2010-08-09T13:08:40Z
dc.date.issued2010-03-26
dc.identifier.citationAn efficient synthetic strategy for obtaining 4-methoxy carbon isotope labeled combretastatin A-4 phosphate and other Z-combretastatins. 2010, 73 (3):399-403 J. Nat. Prod.en
dc.identifier.issn1520-6025
dc.identifier.pmid20028026
dc.identifier.doi10.1021/np9004486
dc.identifier.urihttp://hdl.handle.net/10541/109291
dc.description.abstractHuman cancer and other clinical trials under development employing combretastatin A-4 phosphate (1b, CA4P) should benefit from the availability of a [(11)C]-labeled derivative for positron emission tomography (PET). In order to obtain a suitable precursor for addition of a [(11)C]methyl group at the penultimate step, several new synthetic pathways to CA4P were evaluated. Geometrical isomerization (Z to E) proved to be a challenge, but it was overcome by development of a new CA4P synthesis suitable for 4-methoxy isotope labeling.
dc.language.isoenen
dc.subject.meshBibenzyls
dc.subject.meshIsotope Labeling
dc.subject.meshMolecular Structure
dc.subject.meshPositron-Emission Tomography
dc.subject.meshStereoisomerism
dc.subject.meshStilbenes
dc.titleAn efficient synthetic strategy for obtaining 4-methoxy carbon isotope labeled combretastatin A-4 phosphate and other Z-combretastatins.en
dc.typeArticleen
dc.contributor.departmentCancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604, USA. bpettit@asu.eduen
dc.identifier.journalJournal of Natural Productsen
html.description.abstractHuman cancer and other clinical trials under development employing combretastatin A-4 phosphate (1b, CA4P) should benefit from the availability of a [(11)C]-labeled derivative for positron emission tomography (PET). In order to obtain a suitable precursor for addition of a [(11)C]methyl group at the penultimate step, several new synthetic pathways to CA4P were evaluated. Geometrical isomerization (Z to E) proved to be a challenge, but it was overcome by development of a new CA4P synthesis suitable for 4-methoxy isotope labeling.


This item appears in the following Collection(s)

Show simple item record