• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Pleomorphic rhabdomyosarcoma showing smooth-muscle and fibrohistiocytic differentiation: a single case report.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Eyden, Brian P
    Affiliation
    Department of Histopathology, The Christie NHS Foundation Trust, Manchester, United Kingdom. brian.eyden@christie.nhs.uk
    Issue Date
    2010-02
    
    Metadata
    Show full item record
    Abstract
    Rhabdomyosarcoma has traditionally been subclassified into alveolar, embryonal, and pleomorphic variants. Less commonly, spindle-cell, neuroendocrine, sclerosing, and lipid-rich or clear-cell subtypes are seen. The author recently encountered a myogenic sarcoma, with all the common markers of rhabdomyosarcoma, but expressing the unusual features of alpha-smooth-muscle actin and abundant rough endoplasmic reticulum (rER). This myogenic sarcoma, therefore, exhibited four lines of differentiation, and is documented here. The patient was a 65-year-old man with an inguinal soft tissue mass. Following surgical excision, the patient was given radiotherapy and was well without disease after 6 years. The tumor was positive for vimentin, desmin, alpha-smooth-muscle actin, alpha-sarcomeric actin, myogenin, MyoD1, and CD68. Cytoplasm was dominated by abundant rER intermingled with lipid droplets and lysosomes. Cell surfaces exhibited microvillous processes and focal adhesions, but no lamina. Subplasmalemmal smooth-muscle-type myofilaments with focal densities and rare sarcomeric filaments were seen. The low level of expression of some markers was interpreted as consistent with a poorly differentiated tumor. Given the four lines of differentiation--striated muscle, smooth muscle, fibroblastic, and histiocytic--a name reflecting its phenotype would be pleomorphic rhabdomyosarcoma showing smooth-muscle and fibrohistiocytic differentiation.
    Citation
    Pleomorphic rhabdomyosarcoma showing smooth-muscle and fibrohistiocytic differentiation: a single case report. 2010, 34 (1):42-7 Ultrastruct Pathol
    Journal
    Ultrastructural Pathology
    URI
    http://hdl.handle.net/10541/109289
    DOI
    10.3109/01913120903353795
    PubMed ID
    20070153
    Type
    Article
    Language
    en
    ISSN
    1521-0758
    ae974a485f413a2113503eed53cd6c53
    10.3109/01913120903353795
    Scopus Count
    Collections
    All Christie Publications
    Pathology

    entitlement

    Related articles

    • Intermediate filament proteins and actin isoforms as markers for soft tissue tumor differentiation and origin. II. Rhabdomyosarcomas.
    • Authors: Skalli O, Gabbiani G, Babaï F, Seemayer TA, Pizzolato G, Schürch W
    • Issue date: 1988 Mar
    • Undifferentiated (embryonal) sarcoma of the liver in middle-aged adults: smooth muscle differentiation determined by immunohistochemistry and electron microscopy.
    • Authors: Nishio J, Iwasaki H, Sakashita N, Haraoka S, Isayama T, Naito M, Miyayama H, Yamashita Y, Kikuchi M
    • Issue date: 2003 Mar
    • Myogenic markers in the evaluation of embryonal botryoid rhabdomyosarcoma of the female genital tract.
    • Authors: Riedlinger WF, Kozakewich HP, Vargas SO
    • Issue date: 2005 Jul-Aug
    • Adult-type rhabdomyosarcoma: analysis of 57 cases with clinicopathologic description, identification of 3 morphologic patterns and prognosis.
    • Authors: Stock N, Chibon F, Binh MB, Terrier P, Michels JJ, Valo I, Robin YM, Guillou L, Ranchère-Vince D, Decouvelaere AV, Collin F, Birtwisle-Peyrottes I, Gregoire F, Aurias A, Coindre JM
    • Issue date: 2009 Dec
    • Myogenic markers in the evaluation of embryonal botryoid rhabdomyosarcoma of the female genital tract.
    • Authors: Riedlinger WF, Kozakewich HP, Vargas SO
    • Issue date: 2005 May-Jun
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.