Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics.
Affiliation
Department of Histopathology, The Christie NHS Foundation Trust, Manchester, UK. jonathan.shanks@christie.nhs.ukIssue Date
2009-06
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Show full item recordAbstract
Conventional urothelial carcinoma accounts for most carcinomas of the urinary tract lining. However, neoplastic urothelium has the capacity to demonstrate enormous plasticity. A variety of unusual architectural patterns of urothelial carcinoma, such as the nested, microcystic and inverted variants, can be mistaken for reactive processes or benign tumours. Others such as the micropapillary, plasmacytoid and discohesive variants, can mimic metastatic tumour from other sites. The micropapillary variant in particular is more aggressive. In addition, urothelial carcinoma has a propensity to demonstrate divergent differentiation with glandular, squamous, small cell neuroendocrine, lymphoepithelioma-like, sarcomatoid or other elements. Pure squamous carcinoma or adenocarcinoma (the latter in particular) can be difficult to distinguish from contiguous or metastatic spread. Some variants have prognostic and potential therapeutic implications. Molecular genetic evidence has emerged recently supporting a close relationship between urothelial carcinoma and various divergent elements. Sarcomatoid carcinoma and its differential diagnosis with other spindle cell lesions of urinary tract will be covered in a separate review.Citation
Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics. 2009, 54 (7):885-900 HistopathologyJournal
HistopathologyDOI
10.1111/j.1365-2559.2008.03167.xPubMed ID
19178589Type
ArticleLanguage
enISSN
1365-2559ae974a485f413a2113503eed53cd6c53
10.1111/j.1365-2559.2008.03167.x
Scopus Count
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