Lifestyle factors and colorectal cancer risk (2): a systematic review and meta-analysis of associations with leisure-time physical activity.
AuthorsHarriss, D J
Cable, N Tim
Renehan, Andrew G
AffiliationResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
MetadataShow full item record
AbstractOBJECTIVE: Increased physical activity may decrease the risk of colorectal cancer. As a prerequisite to the determination of lifestyle attributable risks, we performed a systematic review and meta-analysis of prospective observational studies to quantify gender-specific risk associated with increased leisure-time physical activity (LT-PA). METHOD: We searched MEDLINE and EMBASE (to December 2007), and other sources, selecting reports based on strict inclusion criteria. We used random-effects meta-analyses to estimate summary risk ratios (RR) and 95% confidence intervals (95% CI) for uppermost vs lowermost categories of physical activity. To investigate dose-response, we explored risks ratios as a function of cumulative percentiles of physical activity distribution. RESULTS: Fifteen datasets from 14 articles, including 7873 incident cases, were identified. For colon cancer, there were inverse associations with LT-PA for men (RR: 0.80; 95% CI: 0.67-0.96) and women (0.86; 0.76-0.98). LT-PA did not influence risk of rectal cancer. The dose-response analysis was consistent with linear pattern reductions in risk of colon cancer in both genders. There was evidence of moderate between-study heterogeneity but summary estimates were broadly consistent across potential confounding factors. CONCLUSION: Increased LT-PA is associated with a modest reduction in colon but not rectal cancer risk; a risk reduction, which previously may have been overstated. LT-PA only interventions in public health cancer prevention strategies are unlikely to impact substantially on colorectal cancer incidences.
CitationLifestyle factors and colorectal cancer risk (2): a systematic review and meta-analysis of associations with leisure-time physical activity. 2009, 11 (7):689-701 Colorectal Dis
- Lifestyle factors and colorectal cancer risk (1): systematic review and meta-analysis of associations with body mass index.
- Authors: Harriss DJ, Atkinson G, George K, Cable NT, Reilly T, Haboubi N, Zwahlen M, Egger M, Renehan AG, C-CLEAR group.
- Issue date: 2009 Jul
- Fish consumption and colorectal cancer risk in humans: a systematic review and meta-analysis.
- Authors: Wu S, Feng B, Li K, Zhu X, Liang S, Liu X, Han S, Wang B, Wu K, Miao D, Liang J, Fan D
- Issue date: 2012 Jun
- Domain-specific physical activity and sedentary behaviour in relation to colon and rectal cancer risk: a systematic review and meta-analysis.
- Authors: Mahmood S, MacInnis RJ, English DR, Karahalios A, Lynch BM
- Issue date: 2017 Dec 1
- Commentary: How obesity and physical activity contribute to colorectal cancer.
- Authors: Pisani P
- Issue date: 2009 Sep
- Is diabetes mellitus an independent risk factor for colon cancer and rectal cancer?
- Authors: Yuhara H, Steinmaus C, Cohen SE, Corley DA, Tei Y, Buffler PA
- Issue date: 2011 Nov