Associations of anthropometric parameters with serum TSH, prolactin, IGF-I, and testosterone levels: results of the study of health in Pomerania (SHIP).
Affiliation1Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Germany. email@example.com
MetadataShow full item record
AbstractObesity is a major risk factor for chronic diseases including cardiovascular disorders. Divergent associations between obesity and hormonal changes have been reported. The objective of the present study was to analyse the associations between anthropometric measurements and hormone levels including serum thyroid stimulating hormone (TSH), prolactin, insulin-like growth factor (IGF) I, and testosterone. Form the cross-sectional Study of Health in Pomerania 1 women and 1 864 men aged 20-79 years were included in the analyses. Serum TSH, prolactin, IGF-I, and testosterone levels were determined by immunochemiluminescent procedures. Body height, weight as well as waist and hip circumferences were measured. Body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) were calculated. Our analyses revealed inverse linear associations of waist and hip circumferences, BMI and WHtR with serum TSH levels and linear associations between waist circumference as well as WHtR and serum prolactin levels in women. In men, inverse linear and quadratic associations between anthropometric parameters and serum IGF-I as well as serum testosterone levels were found. Additionally, men with high waist circumference had more often low serum IGF-I or testosterone levels and less often high serum IGF-I or testosterone levels compared to men with low waist circumference. These sex-specific differences should be noted in studies regarding hormones and obesity.
CitationAssociations of anthropometric parameters with serum TSH, prolactin, IGF-I, and testosterone levels: results of the study of health in Pomerania (SHIP). 2010, 118 (4):266-73 Exp Clin Endocrinol Diabetes
JournalExperimental and Clinical Endocrinology & Diabetes
- Determinants of sex hormone-binding globulin concentrations in a cross-sectional study of healthy men randomly selected.
- Authors: Gomez JM, Maravall FJ, Gomez N, Navarro MA, Soler J
- Issue date: 2007 Jan-Feb
- Insulin-like growth factor I and anthropometric parameters in a Danish population.
- Authors: Friedrich N, Jørgensen T, Juul A, Spielhagen C, Nauck M, Wallaschofski H, Linneberg A
- Issue date: 2012 Mar
- Gender differences in the relation of insulin-like growth factor binding protein-1 to cardiovascular risk factors: a population-based study.
- Authors: Undén AL, Elofsson S, Brismar K
- Issue date: 2005 Jul
- Body shape throughout life and correlations with IGFs and GH.
- Authors: Schernhammer ES, Tworoger SS, Eliassen AH, Missmer SA, Holly JM, Pollak MN, Hankinson SE
- Issue date: 2007 Sep
- Body mass index, waist circumference and waist to hip ratio and change in sex steroid hormones: the Massachusetts Male Ageing Study.
- Authors: Derby CA, Zilber S, Brambilla D, Morales KH, McKinlay JB
- Issue date: 2006 Jul