• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Spermatogonial apoptosis has three morphologically recognizable phases and shows no circadian rhythm during normal spermatogenesis in the rat.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Allan, D J
    Harmon, B V
    Roberts, Stephen A
    Affiliation
    Centre for Molecular Biotechnology, Queensland University of Technology, Brisbane, Australia.
    Issue Date
    1992-05
    
    Metadata
    Show full item record
    Abstract
    In this study we examined the possibility that regular or circadian fluctuations occur in the frequency of spontaneous spermatogonial apoptosis. Apoptosis of A2, A3 and A4 type spermatogonia occurring spontaneously in the normal rat testis was studied by light and electron microscopy. Normal and apoptotic A3 spermatogonia were quantified in 36 animals killed at two-hourly intervals over a 24 h period. Three sequential phases of spermatogonial apoptosis were defined and quantified separately: (i) an early phase in which cells showed margination of nuclear chromatin, (ii) an intermediate phase in which phagocytosed apoptotic bodies were partly degraded and (iii) a late phase in which only debris of degraded apoptotic bodies was evident. Groups of spermatogonia linked by intercellular bridges underwent apoptosis synchronously. Normal and apoptotic A3 spermatogonia occurred at a mean frequency of 33.4 and 9.6 per 10 seminiferous tubule profiles respectively; there was a large variation in these frequencies between animals, but no peaks or circadian periodicity were detected. Progressive degradation of apoptotic bodies was evident, the average ratios of intermediate and late bodies to early bodies being 1.5 and 3.5, respectively. Absence of a circadian rhythm in these data does not exclude the possibility that initiation of apoptosis in susceptible spermatogonial clones is synchronous, and that affected clones undergo lag periods of differing duration before expressing morphological apoptosis.
    Citation
    Spermatogonial apoptosis has three morphologically recognizable phases and shows no circadian rhythm during normal spermatogenesis in the rat. 1992, 25 (3):241-50 Cell Prolif.
    Journal
    Cell Proliferation
    URI
    http://hdl.handle.net/10541/109029
    DOI
    10.1111/j.1365-2184.1992.tb01399.x
    PubMed ID
    1596537
    Type
    Article
    Language
    en
    ISSN
    0960-7722
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2184.1992.tb01399.x
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Spermatogonial behavior in marmoset: a new generation, their kinetics and niche.
    • Authors: Caldeira-Brant AL, Eras-Garcia L, Alves-Freitas D, Almeida FRCL, Chiarini-Garcia H
    • Issue date: 2018 Jun 1
    • FSH immunoneutralization acutely impairs spermatogonial development in normal adult rats.
    • Authors: Meachem SJ, Mclachlan RI, Stanton PG, Robertson DM, Wreford NG
    • Issue date: 1999 Nov-Dec
    • Characterizing the Spermatogonial Response to Retinoic Acid During the Onset of Spermatogenesis and Following Synchronization in the Neonatal Mouse Testis.
    • Authors: Agrimson KS, Onken J, Mitchell D, Topping TB, Chiarini-Garcia H, Hogarth CA, Griswold MD
    • Issue date: 2016 Oct
    • The morphology and kinetics of spermatogonial degeneration in normal adult rats: an analysis using a simplified classification of the germinal epithelium.
    • Authors: Huckins C
    • Issue date: 1978 Apr
    • Intercellular bridges and apoptosis in clones of male germ cells.
    • Authors: Hamer G, Roepers-Gajadien HL, Gademan IS, Kal HB, De Rooij DG
    • Issue date: 2003 Dec
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.