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    Tumour-infiltrating lymphocytes in cervical carcinoma.

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    Authors
    Ghosh, Anna K
    Moore, M
    Affiliation
    Department of Immunology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, U.K.
    Issue Date
    1992
    
    Metadata
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    Abstract
    Tumour-infiltrating lymphocytes from cervical carcinomas were cultivated in the presence of interleukin-2. The majority of bulk cultures were cytotoxic against K562, Mel 1 and Caski cells. CD8+ cells were the predominant subset in over 50% of cultures, with varying numbers of CD56+ and CD25+ cells. T cell clones were established from six tumour-infiltrating lymphocyte cultures and the majority exhibited non-MHC-restricted cytotoxicity. However, in one case cytotoxicity of several derived clones was limited to the autologous tumour and in another, to the autologous tumour and Caski cells. This study indicates that tumour-infiltrating lymphocytes can be amplified and cloned from cervical carcinoma biopsies in the presence of rIL2. Although the predominant cytolytic function is non-MHC-restricted, low autotumour cytotoxicity can be demonstrated at the clonal level. The nature of the antigen(s) recognised by T cells on autologous cervical carcinoma cells in unknown; the candidacy of human papillomavirus-related products requires investigation.
    Citation
    Tumour-infiltrating lymphocytes in cervical carcinoma. 1992, 28A (11):1910-6 Eur. J. Cancer
    Journal
    European Journal of Cancer
    URI
    http://hdl.handle.net/10541/109020
    DOI
    10.1016/0959-8049(92)90034-Y
    PubMed ID
    1389534
    Type
    Article
    Language
    en
    ISSN
    0959-8049
    ae974a485f413a2113503eed53cd6c53
    10.1016/0959-8049(92)90034-Y
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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