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dc.contributor.authorGlew, Susan Sen
dc.contributor.authorDuggan-Keen, Margaret Fen
dc.contributor.authorCabrera, Ten
dc.contributor.authorStern, Peter Len
dc.date.accessioned2010-08-04T09:15:58Z
dc.date.available2010-08-04T09:15:58Z
dc.date.issued1992-07-15
dc.identifier.citationHLA class II antigen expression in human papillomavirus-associated cervical cancer. 1992, 52 (14):4009-16 Cancer Res.en
dc.identifier.issn0008-5472
dc.identifier.pmid1377602
dc.identifier.urihttp://hdl.handle.net/10541/109017
dc.description.abstractThe observation that tumor cells of some neoplasms display major histocompatibility complex (MHC) class II molecules may be of functional significance, influencing the progression of malignancy by allowing the cancer cells to present antigen to the immune system. In the normal cervix, class II molecules are expressed by columnar but not squamous epithelium. The pattern of MHC class II expression in cervical carcinomas has been documented using immunohistochemical methods. Of 53 cervical squamous carcinomas examined for MHC class II expression, only 17% maintained a negative phenotype characteristic of the epithelium from which they were derived, while the remaining tumors exhibited either uniform (45%) or heterogeneous (38%) expression. Tumor areas which were class II positive also express class II associated invariant chain and the adhesion molecules lymphocyte function antigen 3 and intercellular adhesion molecule 1. The DR, DP, and DQ class II MHC subloci are differentially expressed, suggesting independent regulation. There is a trend for tumors with the uniform class II phenotype to predominantly express DR antigen, whereas tumors of the heterogeneous class II phenotype express with equal frequency either DR or DP antigens dominantly. There is no apparent influence of class II status on lymphocyte infiltration of the tumors. The presence of human papillomavirus 16 DNA in the cervical carcinoma specimens was analyzed by Southern blotting of restriction enzyme digested DNA and no correlation between the presence of human papilloma virus and MHC class II expression was found.
dc.language.isoenen
dc.subjectTumour Virus Infectionsen
dc.subjectUterine Cervical Canceren
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAntigens, CD58
dc.subject.meshAntigens, Surface
dc.subject.meshCarcinoma, Squamous Cell
dc.subject.meshCell Adhesion Molecules
dc.subject.meshCervix Uteri
dc.subject.meshDNA, Viral
dc.subject.meshFemale
dc.subject.meshHLA-DP Antigens
dc.subject.meshHLA-DQ Antigens
dc.subject.meshHLA-DR Antigens
dc.subject.meshHistocompatibility Antigens Class I
dc.subject.meshHistocompatibility Antigens Class II
dc.subject.meshHumans
dc.subject.meshIntercellular Adhesion Molecule-1
dc.subject.meshLeukocyte Count
dc.subject.meshLymphocytes, Tumor-Infiltrating
dc.subject.meshMembrane Glycoproteins
dc.subject.meshMiddle Aged
dc.subject.meshPapillomaviridae
dc.subject.meshPhenotype
dc.subject.meshTumor Virus Infections
dc.subject.meshUterine Cervical Neoplasms
dc.titleHLA class II antigen expression in human papillomavirus-associated cervical cancer.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Immunology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.en
dc.identifier.journalCancer Researchen
html.description.abstractThe observation that tumor cells of some neoplasms display major histocompatibility complex (MHC) class II molecules may be of functional significance, influencing the progression of malignancy by allowing the cancer cells to present antigen to the immune system. In the normal cervix, class II molecules are expressed by columnar but not squamous epithelium. The pattern of MHC class II expression in cervical carcinomas has been documented using immunohistochemical methods. Of 53 cervical squamous carcinomas examined for MHC class II expression, only 17% maintained a negative phenotype characteristic of the epithelium from which they were derived, while the remaining tumors exhibited either uniform (45%) or heterogeneous (38%) expression. Tumor areas which were class II positive also express class II associated invariant chain and the adhesion molecules lymphocyte function antigen 3 and intercellular adhesion molecule 1. The DR, DP, and DQ class II MHC subloci are differentially expressed, suggesting independent regulation. There is a trend for tumors with the uniform class II phenotype to predominantly express DR antigen, whereas tumors of the heterogeneous class II phenotype express with equal frequency either DR or DP antigens dominantly. There is no apparent influence of class II status on lymphocyte infiltration of the tumors. The presence of human papillomavirus 16 DNA in the cervical carcinoma specimens was analyzed by Southern blotting of restriction enzyme digested DNA and no correlation between the presence of human papilloma virus and MHC class II expression was found.


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