HLA class II antigen expression in human papillomavirus-associated cervical cancer.
AffiliationCancer Research Campaign Department of Immunology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.
MetadataShow full item record
AbstractThe observation that tumor cells of some neoplasms display major histocompatibility complex (MHC) class II molecules may be of functional significance, influencing the progression of malignancy by allowing the cancer cells to present antigen to the immune system. In the normal cervix, class II molecules are expressed by columnar but not squamous epithelium. The pattern of MHC class II expression in cervical carcinomas has been documented using immunohistochemical methods. Of 53 cervical squamous carcinomas examined for MHC class II expression, only 17% maintained a negative phenotype characteristic of the epithelium from which they were derived, while the remaining tumors exhibited either uniform (45%) or heterogeneous (38%) expression. Tumor areas which were class II positive also express class II associated invariant chain and the adhesion molecules lymphocyte function antigen 3 and intercellular adhesion molecule 1. The DR, DP, and DQ class II MHC subloci are differentially expressed, suggesting independent regulation. There is a trend for tumors with the uniform class II phenotype to predominantly express DR antigen, whereas tumors of the heterogeneous class II phenotype express with equal frequency either DR or DP antigens dominantly. There is no apparent influence of class II status on lymphocyte infiltration of the tumors. The presence of human papillomavirus 16 DNA in the cervical carcinoma specimens was analyzed by Southern blotting of restriction enzyme digested DNA and no correlation between the presence of human papilloma virus and MHC class II expression was found.
CitationHLA class II antigen expression in human papillomavirus-associated cervical cancer. 1992, 52 (14):4009-16 Cancer Res.
- Langerhans' cell count and HLA class II profile in cervical intraepithelial neoplasia in the presence or absence of HIV infection.
- Authors: Gonçalves MA, Soares EG, Fernandes AP, Fonseca BA, Bettini JS, Simões RT, Donadi EA
- Issue date: 2004 Jun 15
- Dynamics of selected MHC class I and II molecule expression in the course of HPV positive CIN treatment with the use of human recombinant IFN-gamma.
- Authors: Sikorski M, Bobek M, Zrubek H, Marcinkiewicz J
- Issue date: 2004 Mar
- Expression and function of class II antigens on gastric carcinoma cells and gastric epithelia: differential expression of DR, DQ, and DP antigens.
- Authors: Sakai K, Takiguchi M, Mori S, Kobori O, Morioka Y, Inoko H, Sekiguchi M, Kano K
- Issue date: 1987 Nov
- Induction of MHC class II molecules HLA-DR, -DP and -DQ and ICAM 1 in human podocytes by gamma-interferon.
- Authors: Baudeau C, Delarue F, Hé CJ, Nguyen G, Adida C, Peraldi MN, Sraer JD, Rondeau E
- Issue date: 1994 Sep-Oct
- Nonimmune human cells can express MHC class II antigens in the absence of invariant chain--an immunohistological study on normal and chronically inflamed small intestine.
- Authors: Momburg F, Koretz K, Von Herbay A, Möller P
- Issue date: 1988 Jun