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    Vascular function and tissue injury in murine skin following hyperthermia and photodynamic therapy, alone and in combination.

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    Authors
    Moore, James V
    West, Catharine M L
    Haylett, Ann K
    Affiliation
    Paterson Institute for Cancer Research (Cancer Research Campaign), Christie Hospital (NHS) Trust, Manchester, UK.
    Issue Date
    1992-12
    
    Metadata
    Show full item record
    Abstract
    The murine tail has been used as a model for injury to skin when hyperthermia (HT) and photodynamic therapy (PDT) using haematoporphyrin derivative, are used in combination. Skin injury by either agent alone was quantitated by the probability of tail necrosis as a function of dose of agent. 'Tolerance' doses of each modality were given and changes in skin vascular function were measured by the rate of clearance of 133Xenon. This was promptly inhibited but restored to normal by 7 days. The absolute numbers of hypodermal vessels of different sizes were measured in tail cross-sections and capillary numbers were found to be greatly reduced between 1 and 7 days, and restored to normal by 21-28 days. When a tolerance dose of PDT was followed at 1, 7, 21 and 28 days by test doses of HT, or vice versa, marked enhancements in probability of necrosis were observed when the interval was 1 or 7 days (Enhancement ratio (ER)PDT-HT = 1.5 and ERHT-PDT = 1.8). Prolonging the interval between modalities to 21-28 days spared the tissue (ERHT-PDT/21 DAYS = 1.1; ERPDT-HT/28 DAYS = 1.0). Close temporal apposition of PDT and HT, such as has been advocated to improve tumour control, may also increase injury to normal tissue through vascular effects common to both.
    Citation
    Vascular function and tissue injury in murine skin following hyperthermia and photodynamic therapy, alone and in combination. 1992, 66 (6):1037-43 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/109015
    PubMed ID
    1457342
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Paterson Institute for Cancer Research

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