• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    A model of the control of cellular regeneration in the intestinal crypt after perturbation based solely on local stem cell regulation.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Paulus, U
    Potten, Christopher S
    Loeffler, M
    Affiliation
    Department of Biometry, Medizinische Universitaetsklinik I, Cologne, Germany.
    Issue Date
    1992-11
    
    Metadata
    Show full item record
    Abstract
    The control mechanisms involved in regeneration of murine intestinal crypts after perturbations are presently not well understood. The existence of some feedback signals from the cells on the villus to the cells in the crypt has been suggested. However, some recent experimental data point to the fact that regeneration in the crypt starts very early after perturbation, at a time when the villus cell population has hardly changed. In particular, this early cell proliferative activity is seen specifically at the bottom of the crypt, i.e. in the presumed stem cell zone and furthest from the villus. The objective of this study was to investigate whether a new concept of regulation operating solely at the stem cell level could explain the present mass of accumulated data on the post-irradiation recovery, which is an extensively studied perturbation from the experimental point of view. In order to check its validity, the new concept was formalized as a mathematical simulation model thus enabling comparison with experimental data. The model describes the cellular development from stem cells to the mature villus cells. As a basic feature it is assumed that the self-maintenance and the cell cycle activity of the stem cells are controlled by the number of these cells in an autoregulatory fashion. The essential features of the experimental data (i.e. the recovery with time and the consistency between different types of measurements) can be very well reproduced by simulations using a range of model parameters. Thus, we conclude that stem cell autoregulation is a valid concept which could replace the villus crypt feedback concept in explaining the early changes after irradiation when the damage primarily affects the crypt. The question of the detailed nature of the control process requires further investigation.
    Citation
    A model of the control of cellular regeneration in the intestinal crypt after perturbation based solely on local stem cell regulation. 1992, 25 (6):559-78 Cell Prolif.
    Journal
    Cell Proliferation
    URI
    http://hdl.handle.net/10541/109003
    DOI
    10.1111/j.1365-2184.1992.tb01460.x
    PubMed ID
    1457605
    Type
    Article
    Language
    en
    ISSN
    0960-7722
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2184.1992.tb01460.x
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Somatic mutation, monoclonality and stochastic models of stem cell organization in the intestinal crypt.
    • Authors: Loeffler M, Birke A, Winton D, Potten C
    • Issue date: 1993 Feb 21
    • The crypt cycle. Crypt and villus production in the adult intestinal epithelium.
    • Authors: Totafurno J, Bjerknes M, Cheng H
    • Issue date: 1987 Aug
    • Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1.
    • Authors: Cohn SM, Schloemann S, Tessner T, Seibert K, Stenson WF
    • Issue date: 1997 Mar 15
    • In Vivo Imaging Reveals Existence of Crypt Fission and Fusion in Adult Mouse Intestine.
    • Authors: Bruens L, Ellenbroek SIJ, van Rheenen J, Snippert HJ
    • Issue date: 2017 Sep
    • The effect of continuous irradiation on cell proliferation and maturation in small intestinal epithelium.
    • Authors: Rijke RP, Plaisier H, Hoogeveen AT, Lamerton LF, Galjaard H
    • Issue date: 1975 Sep
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.