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dc.contributor.authorPotten, Christopher Sen
dc.date.accessioned2010-08-04T09:14:06Z
dc.date.available2010-08-04T09:14:06Z
dc.date.issued1992-09
dc.identifier.citationThe significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. 1992, 11 (2):179-95 Cancer Metastasis Rev.en
dc.identifier.issn0167-7659
dc.identifier.pmid1394796
dc.identifier.doi10.1007/BF00048063
dc.identifier.urihttp://hdl.handle.net/10541/108996
dc.description.abstractThe crypts of the gastrointestinal mucosa are highly structured and polarised organs with rapid cell proliferation and an hierarchical organisation with relatively few stem cells. These tend to be located at specific positions in the tissue--at the crypt base in the colon and about four cell positions from the base (above the Paneth cells) in the small intestine. A small but constant level of spontaneous cell death occurs in the crypt. The levels of cell death are elevated by small exposures to radiation or cytotoxic drugs. The morphology of the cell death is typical of apoptosis. The maximum yield of cell death following cytotoxic exposure is observed at about 3-6 h after treatment and for many agents the death is characteristically located at the fourth (stem) cell position in the small intestine. The significance and implications of these observations are discussed in relation to the internal screening and programming within damage cells and with respect to tissue homeostatic mechanisms.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshApoptosis
dc.subject.meshDNA Damage
dc.subject.meshGastric Mucosa
dc.subject.meshIntestinal Mucosa
dc.subject.meshMice
dc.subject.meshMutagens
dc.titleThe significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.en
dc.identifier.journalCancer Metastasis Reviewsen
html.description.abstractThe crypts of the gastrointestinal mucosa are highly structured and polarised organs with rapid cell proliferation and an hierarchical organisation with relatively few stem cells. These tend to be located at specific positions in the tissue--at the crypt base in the colon and about four cell positions from the base (above the Paneth cells) in the small intestine. A small but constant level of spontaneous cell death occurs in the crypt. The levels of cell death are elevated by small exposures to radiation or cytotoxic drugs. The morphology of the cell death is typical of apoptosis. The maximum yield of cell death following cytotoxic exposure is observed at about 3-6 h after treatment and for many agents the death is characteristically located at the fourth (stem) cell position in the small intestine. The significance and implications of these observations are discussed in relation to the internal screening and programming within damage cells and with respect to tissue homeostatic mechanisms.


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