The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice.
AuthorsPotten, Christopher S
AffiliationCRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.
MetadataShow full item record
AbstractThe crypts of the gastrointestinal mucosa are highly structured and polarised organs with rapid cell proliferation and an hierarchical organisation with relatively few stem cells. These tend to be located at specific positions in the tissue--at the crypt base in the colon and about four cell positions from the base (above the Paneth cells) in the small intestine. A small but constant level of spontaneous cell death occurs in the crypt. The levels of cell death are elevated by small exposures to radiation or cytotoxic drugs. The morphology of the cell death is typical of apoptosis. The maximum yield of cell death following cytotoxic exposure is observed at about 3-6 h after treatment and for many agents the death is characteristically located at the fourth (stem) cell position in the small intestine. The significance and implications of these observations are discussed in relation to the internal screening and programming within damage cells and with respect to tissue homeostatic mechanisms.
CitationThe significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. 1992, 11 (2):179-95 Cancer Metastasis Rev.
JournalCancer Metastasis Reviews
- Effect of paclitaxel (taxol) alone and in combination with radiation on the gastrointestinal mucosa.
- Authors: Mason KA, Milas L, Peters LJ
- Issue date: 1995 Jul 30
- The relationship between ionizing radiation-induced apoptosis and stem cells in the small and large intestine.
- Authors: Potten CS, Grant HK
- Issue date: 1998 Oct
- Stem cells in gastrointestinal epithelium: numbers, characteristics and death.
- Authors: Potten CS
- Issue date: 1998 Jun 29
- [Radiation-induced gastrointestinal syndrome: who is the culprit?].
- Authors: François A, Milliat F
- Issue date: 2010 May
- Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation.
- Authors: Ijiri K, Potten CS
- Issue date: 1983 Feb