The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice.
Authors
Potten, Christopher SAffiliation
CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.Issue Date
1992-09
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The crypts of the gastrointestinal mucosa are highly structured and polarised organs with rapid cell proliferation and an hierarchical organisation with relatively few stem cells. These tend to be located at specific positions in the tissue--at the crypt base in the colon and about four cell positions from the base (above the Paneth cells) in the small intestine. A small but constant level of spontaneous cell death occurs in the crypt. The levels of cell death are elevated by small exposures to radiation or cytotoxic drugs. The morphology of the cell death is typical of apoptosis. The maximum yield of cell death following cytotoxic exposure is observed at about 3-6 h after treatment and for many agents the death is characteristically located at the fourth (stem) cell position in the small intestine. The significance and implications of these observations are discussed in relation to the internal screening and programming within damage cells and with respect to tissue homeostatic mechanisms.Citation
The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. 1992, 11 (2):179-95 Cancer Metastasis Rev.Journal
Cancer Metastasis ReviewsDOI
10.1007/BF00048063PubMed ID
1394796Type
ArticleLanguage
enISSN
0167-7659ae974a485f413a2113503eed53cd6c53
10.1007/BF00048063
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