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dc.contributor.authorBadawi, Alaa Fen
dc.contributor.authorMostafa, M Hen
dc.contributor.authorO'Connor, Peter Jen
dc.date.accessioned2010-08-04T09:12:32Z
dc.date.available2010-08-04T09:12:32Z
dc.date.issued1992-04-30
dc.identifier.citationInvolvement of alkylating agents in schistosome-associated bladder cancer: the possible basic mechanisms of induction. 1992, 63 (3):171-88 Cancer Lett.en
dc.identifier.issn0304-3835
dc.identifier.pmid1576589
dc.identifier.doi10.1016/0304-3835(92)90259-X
dc.identifier.urihttp://hdl.handle.net/10541/108995
dc.description.abstractCarcinoma of the urinary bladder is a common malignancy in many tropical and subtropical countries. There is a well documented sequela of chronic urinary schistosomal infection and bladder cancer associated with schistosomiasis is a major cause of morbidity and mortality in the endemic areas. Experimental bladder cancer can be induced in schistosome-infected animals. Multiple factors have been suggested as causative agents in schistosome-associated bladder carcinogenesis and the N-nitroso compounds appear to be of particular importance. These agents have long been suspected to play a major role in the aetiology of a variety of human cancers. A model for the induction of bladder cancer associated with schistosomiasis is proposed which takes into account the interrelationships between different factors resulting from the infection, especially the role of alkylating agents that can contribute to the induction of this neoplasm.
dc.language.isoenen
dc.subjectUrinary Bladder Canceren
dc.subject.meshAlkylating Agents
dc.subject.meshDNA Damage
dc.subject.meshDNA Repair
dc.subject.meshHumans
dc.subject.meshMethyltransferases
dc.subject.meshNitrosamines
dc.subject.meshNitroso Compounds
dc.subject.meshO(6)-Methylguanine-DNA Methyltransferase
dc.subject.meshSchistosomiasis
dc.subject.meshUrinary Bladder Neoplasms
dc.titleInvolvement of alkylating agents in schistosome-associated bladder cancer: the possible basic mechanisms of induction.en
dc.typeArticleen
dc.contributor.departmentDepartment of Environmental Studies, Alexandria University, Egypt.en
dc.identifier.journalCancer Lettersen
html.description.abstractCarcinoma of the urinary bladder is a common malignancy in many tropical and subtropical countries. There is a well documented sequela of chronic urinary schistosomal infection and bladder cancer associated with schistosomiasis is a major cause of morbidity and mortality in the endemic areas. Experimental bladder cancer can be induced in schistosome-infected animals. Multiple factors have been suggested as causative agents in schistosome-associated bladder carcinogenesis and the N-nitroso compounds appear to be of particular importance. These agents have long been suspected to play a major role in the aetiology of a variety of human cancers. A model for the induction of bladder cancer associated with schistosomiasis is proposed which takes into account the interrelationships between different factors resulting from the infection, especially the role of alkylating agents that can contribute to the induction of this neoplasm.


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