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dc.contributor.authorHendry, Jolyon H
dc.contributor.authorRoberts, Stephen A
dc.contributor.authorPotten, Christopher S
dc.date.accessioned2010-08-03T11:54:50Z
dc.date.available2010-08-03T11:54:50Z
dc.date.issued1992-10
dc.identifier.citationThe clonogen content of murine intestinal crypts: dependence on radiation dose used in its determination. 1992, 132 (1):115-9 Radiat. Res.en
dc.identifier.issn0033-7587
dc.identifier.pmid1410267
dc.identifier.urihttp://hdl.handle.net/10541/108928
dc.description.abstractThe number of colony-forming (clonogenic) cells in each of the crypts in mouse small intestine was deduced using a two-dose irradiation technique. The number was 7.5 +/- 0.8 cells using two equal doses each less than 9 Gy and 38 +/- 7 cells using 9 Gy or more per dose. The significant dose dependence could not be accounted for by considerations of intra- or intercrypt variability, or by the factor introduced to correct the sampling frequency for the influence of crypt size. The results suggest that more colony-forming cells may be recruited when the injury is more severe.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshColony-Forming Units Assay
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshIntestine, Small
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshStem Cells
dc.titleThe clonogen content of murine intestinal crypts: dependence on radiation dose used in its determination.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, United Kingdom.en
dc.identifier.journalRadiation Researchen
html.description.abstractThe number of colony-forming (clonogenic) cells in each of the crypts in mouse small intestine was deduced using a two-dose irradiation technique. The number was 7.5 +/- 0.8 cells using two equal doses each less than 9 Gy and 38 +/- 7 cells using 9 Gy or more per dose. The significant dose dependence could not be accounted for by considerations of intra- or intercrypt variability, or by the factor introduced to correct the sampling frequency for the influence of crypt size. The results suggest that more colony-forming cells may be recruited when the injury is more severe.


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