The clonogen content of murine intestinal crypts: dependence on radiation dose used in its determination.
dc.contributor.author | Hendry, Jolyon H | |
dc.contributor.author | Roberts, Stephen A | |
dc.contributor.author | Potten, Christopher S | |
dc.date.accessioned | 2010-08-03T11:54:50Z | |
dc.date.available | 2010-08-03T11:54:50Z | |
dc.date.issued | 1992-10 | |
dc.identifier.citation | The clonogen content of murine intestinal crypts: dependence on radiation dose used in its determination. 1992, 132 (1):115-9 Radiat. Res. | en |
dc.identifier.issn | 0033-7587 | |
dc.identifier.pmid | 1410267 | |
dc.identifier.uri | http://hdl.handle.net/10541/108928 | |
dc.description.abstract | The number of colony-forming (clonogenic) cells in each of the crypts in mouse small intestine was deduced using a two-dose irradiation technique. The number was 7.5 +/- 0.8 cells using two equal doses each less than 9 Gy and 38 +/- 7 cells using 9 Gy or more per dose. The significant dose dependence could not be accounted for by considerations of intra- or intercrypt variability, or by the factor introduced to correct the sampling frequency for the influence of crypt size. The results suggest that more colony-forming cells may be recruited when the injury is more severe. | |
dc.language.iso | en | en |
dc.subject.mesh | Animals | |
dc.subject.mesh | Colony-Forming Units Assay | |
dc.subject.mesh | Dose-Response Relationship, Radiation | |
dc.subject.mesh | Intestine, Small | |
dc.subject.mesh | Male | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Stem Cells | |
dc.title | The clonogen content of murine intestinal crypts: dependence on radiation dose used in its determination. | en |
dc.type | Article | en |
dc.contributor.department | Cancer Research Campaign Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, United Kingdom. | en |
dc.identifier.journal | Radiation Research | en |
html.description.abstract | The number of colony-forming (clonogenic) cells in each of the crypts in mouse small intestine was deduced using a two-dose irradiation technique. The number was 7.5 +/- 0.8 cells using two equal doses each less than 9 Gy and 38 +/- 7 cells using 9 Gy or more per dose. The significant dose dependence could not be accounted for by considerations of intra- or intercrypt variability, or by the factor introduced to correct the sampling frequency for the influence of crypt size. The results suggest that more colony-forming cells may be recruited when the injury is more severe. |