The clonogen content of murine intestinal crypts: dependence on radiation dose used in its determination.
Affiliation
Cancer Research Campaign Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, United Kingdom.Issue Date
1992-10
Metadata
Show full item recordAbstract
The number of colony-forming (clonogenic) cells in each of the crypts in mouse small intestine was deduced using a two-dose irradiation technique. The number was 7.5 +/- 0.8 cells using two equal doses each less than 9 Gy and 38 +/- 7 cells using 9 Gy or more per dose. The significant dose dependence could not be accounted for by considerations of intra- or intercrypt variability, or by the factor introduced to correct the sampling frequency for the influence of crypt size. The results suggest that more colony-forming cells may be recruited when the injury is more severe.Citation
The clonogen content of murine intestinal crypts: dependence on radiation dose used in its determination. 1992, 132 (1):115-9 Radiat. Res.Journal
Radiation ResearchPubMed ID
1410267Type
ArticleLanguage
enISSN
0033-7587Collections
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