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    Heparan sulphate in the binding and activation of basic fibroblast growth factor.

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    Authors
    Gallagher, John T
    Turnbull, Jeremy E
    Affiliation
    Department of Medical Oncology, Christie Hospital NHS Trust, Manchester, UK.
    Issue Date
    1992-12
    
    Metadata
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    Abstract
    Heparan sulphate proteoglycans (HSPGs) are widely distributed in animal tissues, but their most prominent locations are cell surface membranes and basement membranes. Their influence on various fundamental aspects of cell behaviour (e.g. cell adhesion, growth and morphogenesis) are dependent on the specific binding properties of the heparan sulphate (HS) chains. These polysaccharides are complex structures in which N-sulphated glucosamine and ester sulphate groups tend to be clustered in discrete regions of the chain separated by sequences enriched in N-acetylglucosamine residues, but with a low sulphate concentration. The sulphated domains contain the sugar residue sequences for interaction with specific proteins essential for HS function. In this review, we describe the plasma membrane HSPGs and their role in regulating the activity of basic fibroblast growth factor (bFGF).
    Citation
    Heparan sulphate in the binding and activation of basic fibroblast growth factor. 1992, 2 (6):523-8 Glycobiology
    Journal
    Glycobiology
    URI
    http://hdl.handle.net/10541/108925
    DOI
    10.1093/glycob/2.6.523
    PubMed ID
    1472758
    Type
    Article
    Language
    en
    ISSN
    0959-6658
    ae974a485f413a2113503eed53cd6c53
    10.1093/glycob/2.6.523
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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