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dc.contributor.authorHadfield, John Aen
dc.contributor.authorFox, Brian Wen
dc.contributor.authorCaffrey, Roberten
dc.date.accessioned2010-08-03T11:07:06Z
dc.date.available2010-08-03T11:07:06Z
dc.date.issued1992-06
dc.identifier.citationDimethanesulphonate esters in receptor mapping studies. 2. Antitumour activities of alkyl and alkoxy dimethanesulphonates substituted on a benzene nucleus. 1992, 7 (3):263-75 Anticancer Drug Des.en
dc.identifier.issn0266-9536
dc.identifier.pmid1610483
dc.identifier.urihttp://hdl.handle.net/10541/108922
dc.description.abstractThe antitumour activities of 15 novel aromatic dimethanesulphonate esters were studied. Several alkyl and alkoxy compounds have shown good antitumour activity whilst similar isomers have proved ineffective as antitumour agents. These differences in activity have been correlated with the length of the sidechain substituents and their relative flexibilities.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshAntineoplastic Agents
dc.subject.meshBenzene
dc.subject.meshDrug Design
dc.subject.meshMethyl Methanesulfonate
dc.subject.meshRats
dc.subject.meshReceptors, Drug
dc.subject.meshStructure-Activity Relationship
dc.titleDimethanesulphonate esters in receptor mapping studies. 2. Antitumour activities of alkyl and alkoxy dimethanesulphonates substituted on a benzene nucleus.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital Trust, Withington, Manchester, UK.en
dc.identifier.journalAnti-Cancer Drug Designen
html.description.abstractThe antitumour activities of 15 novel aromatic dimethanesulphonate esters were studied. Several alkyl and alkoxy compounds have shown good antitumour activity whilst similar isomers have proved ineffective as antitumour agents. These differences in activity have been correlated with the length of the sidechain substituents and their relative flexibilities.


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