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dc.contributor.authorHows, Jill M
dc.contributor.authorMarsh, Judith C W
dc.contributor.authorBradley, B A
dc.contributor.authorLuft, Thomas
dc.contributor.authorCoutinho, Lucia H
dc.contributor.authorTesta, Nydia G
dc.contributor.authorDexter, T Michael
dc.date.accessioned2010-08-03T10:23:08Z
dc.date.available2010-08-03T10:23:08Z
dc.date.issued1992
dc.identifier.citationHuman cord blood: a source of transplantable stem cells? 1992, 9 Suppl 1:105-8 Bone Marrow Transplant.en
dc.identifier.issn0268-3369
dc.identifier.pmid1354517
dc.identifier.urihttp://hdl.handle.net/10541/108913
dc.description.abstractIn a preliminary study we have shown that optimally collected human umbilical cord (HUC) blood cells grow significantly better in long term cultures (LTC) than normal adult marrow cells (NBM) p = 0.0007. The LTC findings are supported by the observation in clonogenic assay that a similar number of GM-CFC colonies can be grown from HUC blood and NBM mononuclear cells (MNC). Also there is a trend towards a higher proportion of primitive erythroid (BFU-E) and primitive megakaryocyte colonies (MK-CFC containing greater than 20 cells) in HUC blood compared with NBM. We suggest that further work on the feasibility of a HLA typed, cryopreserved HUC blood bank as a source of unrelated haemopoietic 'stem' cells for clinical transplantation is indicated.
dc.language.isoenen
dc.subjectFoetal Blooden
dc.subjectFoetal Tissue Transplantationen
dc.subjectHaematopoietic Stem Cell Transplantationen
dc.subjectHaematopoietic Stem Cellsen
dc.subject.meshBlood Cell Count
dc.subject.meshBlood Specimen Collection
dc.subject.meshCells, Cultured
dc.subject.meshColony-Forming Units Assay
dc.subject.meshFeasibility Studies
dc.subject.meshFetal Blood
dc.subject.meshFetal Tissue Transplantation
dc.subject.meshHematopoietic Stem Cell Transplantation
dc.subject.meshHematopoietic Stem Cells
dc.subject.meshHumans
dc.subject.meshInfant, Newborn
dc.titleHuman cord blood: a source of transplantable stem cells?en
dc.typeArticleen
dc.contributor.departmentKay Kendall Laboratory, Paterson Institute, Cancer Research Campaign, Manchester, UK.en
dc.identifier.journalBone Marrow Transplantationen
html.description.abstractIn a preliminary study we have shown that optimally collected human umbilical cord (HUC) blood cells grow significantly better in long term cultures (LTC) than normal adult marrow cells (NBM) p = 0.0007. The LTC findings are supported by the observation in clonogenic assay that a similar number of GM-CFC colonies can be grown from HUC blood and NBM mononuclear cells (MNC). Also there is a trend towards a higher proportion of primitive erythroid (BFU-E) and primitive megakaryocyte colonies (MK-CFC containing greater than 20 cells) in HUC blood compared with NBM. We suggest that further work on the feasibility of a HLA typed, cryopreserved HUC blood bank as a source of unrelated haemopoietic 'stem' cells for clinical transplantation is indicated.


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