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    Human cord blood: a source of transplantable stem cells?

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    Authors
    Hows, Jill M
    Marsh, Judith C W
    Bradley, B A
    Luft, Thomas
    Coutinho, Lucia H
    Testa, Nydia G
    Dexter, T Michael
    Affiliation
    Kay Kendall Laboratory, Paterson Institute, Cancer Research Campaign, Manchester, UK.
    Issue Date
    1992
    
    Metadata
    Show full item record
    Abstract
    In a preliminary study we have shown that optimally collected human umbilical cord (HUC) blood cells grow significantly better in long term cultures (LTC) than normal adult marrow cells (NBM) p = 0.0007. The LTC findings are supported by the observation in clonogenic assay that a similar number of GM-CFC colonies can be grown from HUC blood and NBM mononuclear cells (MNC). Also there is a trend towards a higher proportion of primitive erythroid (BFU-E) and primitive megakaryocyte colonies (MK-CFC containing greater than 20 cells) in HUC blood compared with NBM. We suggest that further work on the feasibility of a HLA typed, cryopreserved HUC blood bank as a source of unrelated haemopoietic 'stem' cells for clinical transplantation is indicated.
    Citation
    Human cord blood: a source of transplantable stem cells? 1992, 9 Suppl 1:105-8 Bone Marrow Transplant.
    Journal
    Bone Marrow Transplantation
    URI
    http://hdl.handle.net/10541/108913
    PubMed ID
    1354517
    Type
    Article
    Language
    en
    ISSN
    0268-3369
    Collections
    All Paterson Institute for Cancer Research

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