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Cell adhesion in the stromal regulation of haemopoiesis.

dc.contributor.authorClark, B R
dc.contributor.authorGallagher, John T
dc.contributor.authorDexter, T Michael
dc.date.accessioned2010-08-03T10:47:17Z
dc.date.available2010-08-03T10:47:17Z
dc.date.issued1992-07
dc.identifier.citationCell adhesion in the stromal regulation of haemopoiesis. 1992, 5 (3):619-52 Baillieres Clin. Haematol.en
dc.identifier.issn0950-3536
dc.identifier.pmid1457965
dc.identifier.urihttp://hdl.handle.net/10541/108906
dc.description.abstractHaemopoiesis occurs in close physical contact with elements of the bone marrow stroma. This review examines some adhesion molecules which are expressed in haemopoietic environments. These molecules may act to maintain cell contact between haemopoietic progenitors and the cellular and extracellular matrix elements of the marrow stroma. A review is undertaken of several families of adhesion molecules and their ligands, including integrins, CD44, LEC-CAMs, CAMs and variant glycosylation patterns expressed by haemopoietic cells. Both CD44 and integrin receptors have been implicated in mediating important cellular interactions within the haemopoietic system and the significance of these and other molecules in haemopoiesis is discussed.
dc.language.isoenen
dc.subjectHaematologic Diseasesen
dc.subjectHaematopoiesisen
dc.subjectHaematopoietic Cell Growth Factorsen
dc.subjecthaematopoietic Stem Cellsen
dc.subjectHaematopoietic Systemen
dc.subject.meshAmino Acid Sequence
dc.subject.meshAnimals
dc.subject.meshBone Marrow Cells
dc.subject.meshCell Adhesion Molecules
dc.subject.meshConnective Tissue
dc.subject.meshExtracellular Matrix
dc.subject.meshHematologic Diseases
dc.subject.meshHematopoiesis
dc.subject.meshHematopoietic Cell Growth Factors
dc.subject.meshHematopoietic Stem Cells
dc.subject.meshHematopoietic System
dc.subject.meshHumans
dc.subject.meshIntegrins
dc.subject.meshLectins
dc.subject.meshLymphoid Tissue
dc.subject.meshMice
dc.subject.meshMice, Mutant Strains
dc.subject.meshModels, Biological
dc.subject.meshMolecular Sequence Data
dc.subject.meshOrgan Culture Techniques
dc.subject.meshProteoglycans
dc.subject.meshReceptors, Lymphocyte Homing
dc.subject.meshVertebrates
dc.titleCell adhesion in the stromal regulation of haemopoiesis.en
dc.typeArticleen
dc.identifier.journalBaillière's Clinical Haematologyen
html.description.abstractHaemopoiesis occurs in close physical contact with elements of the bone marrow stroma. This review examines some adhesion molecules which are expressed in haemopoietic environments. These molecules may act to maintain cell contact between haemopoietic progenitors and the cellular and extracellular matrix elements of the marrow stroma. A review is undertaken of several families of adhesion molecules and their ligands, including integrins, CD44, LEC-CAMs, CAMs and variant glycosylation patterns expressed by haemopoietic cells. Both CD44 and integrin receptors have been implicated in mediating important cellular interactions within the haemopoietic system and the significance of these and other molecules in haemopoiesis is discussed.


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