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    Cell adhesion in the stromal regulation of haemopoiesis.

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    Authors
    Clark, B R
    Gallagher, John T
    Dexter, T Michael
    Issue Date
    1992-07
    
    Metadata
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    Abstract
    Haemopoiesis occurs in close physical contact with elements of the bone marrow stroma. This review examines some adhesion molecules which are expressed in haemopoietic environments. These molecules may act to maintain cell contact between haemopoietic progenitors and the cellular and extracellular matrix elements of the marrow stroma. A review is undertaken of several families of adhesion molecules and their ligands, including integrins, CD44, LEC-CAMs, CAMs and variant glycosylation patterns expressed by haemopoietic cells. Both CD44 and integrin receptors have been implicated in mediating important cellular interactions within the haemopoietic system and the significance of these and other molecules in haemopoiesis is discussed.
    Citation
    Cell adhesion in the stromal regulation of haemopoiesis. 1992, 5 (3):619-52 Baillieres Clin. Haematol.
    Journal
    Baillière's Clinical Haematology
    URI
    http://hdl.handle.net/10541/108906
    PubMed ID
    1457965
    Type
    Article
    Language
    en
    ISSN
    0950-3536
    Collections
    All Paterson Institute for Cancer Research

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