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dc.contributor.authorHendry, Jolyon Hen
dc.date.accessioned2010-08-03T08:27:24Z
dc.date.available2010-08-03T08:27:24Z
dc.date.issued1992-12
dc.identifier.citationTreatment acceleration in radiotherapy: the relative time factors and dose-response slopes for tumours and normal tissues. 1992, 25 (4):308-12 Radiother Oncolen
dc.identifier.issn0167-8140
dc.identifier.pmid1480778
dc.identifier.doi10.1016/0167-8140(92)90252-P
dc.identifier.urihttp://hdl.handle.net/10541/108895
dc.description.abstractA published collation of data for control of head and neck cancer in over 4500 patients has been subjected to direct analysis to deduce dose-response, fractionation, and time parameters. The analysis confirms the presence of a significant time factor of the order of 0.5-0.6 Gy/day, deduced previously using various assumptions and normalisation procedures. In addition, the dose-response curve was characterised by Da = 29 Gy which contributed to long "effective" doubling times being deduced for tumour clonogens in the patient population as a whole. Some late-reacting normal tissues also show significant time factors, and furthermore, their dose-response curves are in general steeper than for tumours. Hence, care should be taken in accelerating treatments to improve local control, if the treatments are truly at tolerance regarding late-appearing major complications.
dc.language.isoenen
dc.subjectHead and Neck Canceren
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshHead and Neck Neoplasms
dc.subject.meshHumans
dc.subject.meshLikelihood Functions
dc.subject.meshRadiation Effects
dc.subject.meshRadiation Tolerance
dc.subject.meshRadiotherapy Dosage
dc.subject.meshTime Factors
dc.titleTreatment acceleration in radiotherapy: the relative time factors and dose-response slopes for tumours and normal tissues.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.en
dc.identifier.journalRadiotherapy and Oncologyen
html.description.abstractA published collation of data for control of head and neck cancer in over 4500 patients has been subjected to direct analysis to deduce dose-response, fractionation, and time parameters. The analysis confirms the presence of a significant time factor of the order of 0.5-0.6 Gy/day, deduced previously using various assumptions and normalisation procedures. In addition, the dose-response curve was characterised by Da = 29 Gy which contributed to long "effective" doubling times being deduced for tumour clonogens in the patient population as a whole. Some late-reacting normal tissues also show significant time factors, and furthermore, their dose-response curves are in general steeper than for tumours. Hence, care should be taken in accelerating treatments to improve local control, if the treatments are truly at tolerance regarding late-appearing major complications.


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