Treatment acceleration in radiotherapy: the relative time factors and dose-response slopes for tumours and normal tissues.
dc.contributor.author | Hendry, Jolyon H | |
dc.date.accessioned | 2010-08-03T08:27:24Z | |
dc.date.available | 2010-08-03T08:27:24Z | |
dc.date.issued | 1992-12 | |
dc.identifier.citation | Treatment acceleration in radiotherapy: the relative time factors and dose-response slopes for tumours and normal tissues. 1992, 25 (4):308-12 Radiother Oncol | en |
dc.identifier.issn | 0167-8140 | |
dc.identifier.pmid | 1480778 | |
dc.identifier.doi | 10.1016/0167-8140(92)90252-P | |
dc.identifier.uri | http://hdl.handle.net/10541/108895 | |
dc.description.abstract | A published collation of data for control of head and neck cancer in over 4500 patients has been subjected to direct analysis to deduce dose-response, fractionation, and time parameters. The analysis confirms the presence of a significant time factor of the order of 0.5-0.6 Gy/day, deduced previously using various assumptions and normalisation procedures. In addition, the dose-response curve was characterised by Da = 29 Gy which contributed to long "effective" doubling times being deduced for tumour clonogens in the patient population as a whole. Some late-reacting normal tissues also show significant time factors, and furthermore, their dose-response curves are in general steeper than for tumours. Hence, care should be taken in accelerating treatments to improve local control, if the treatments are truly at tolerance regarding late-appearing major complications. | |
dc.language.iso | en | en |
dc.subject | Head and Neck Cancer | en |
dc.subject.mesh | Dose-Response Relationship, Radiation | |
dc.subject.mesh | Head and Neck Neoplasms | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Likelihood Functions | |
dc.subject.mesh | Radiation Effects | |
dc.subject.mesh | Radiation Tolerance | |
dc.subject.mesh | Radiotherapy Dosage | |
dc.subject.mesh | Time Factors | |
dc.title | Treatment acceleration in radiotherapy: the relative time factors and dose-response slopes for tumours and normal tissues. | en |
dc.type | Article | en |
dc.contributor.department | Cancer Research Campaign Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK. | en |
dc.identifier.journal | Radiotherapy and Oncology | en |
html.description.abstract | A published collation of data for control of head and neck cancer in over 4500 patients has been subjected to direct analysis to deduce dose-response, fractionation, and time parameters. The analysis confirms the presence of a significant time factor of the order of 0.5-0.6 Gy/day, deduced previously using various assumptions and normalisation procedures. In addition, the dose-response curve was characterised by Da = 29 Gy which contributed to long "effective" doubling times being deduced for tumour clonogens in the patient population as a whole. Some late-reacting normal tissues also show significant time factors, and furthermore, their dose-response curves are in general steeper than for tumours. Hence, care should be taken in accelerating treatments to improve local control, if the treatments are truly at tolerance regarding late-appearing major complications. |