Treatment acceleration in radiotherapy: the relative time factors and dose-response slopes for tumours and normal tissues.
AuthorsHendry, Jolyon H
AffiliationCancer Research Campaign Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.
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AbstractA published collation of data for control of head and neck cancer in over 4500 patients has been subjected to direct analysis to deduce dose-response, fractionation, and time parameters. The analysis confirms the presence of a significant time factor of the order of 0.5-0.6 Gy/day, deduced previously using various assumptions and normalisation procedures. In addition, the dose-response curve was characterised by Da = 29 Gy which contributed to long "effective" doubling times being deduced for tumour clonogens in the patient population as a whole. Some late-reacting normal tissues also show significant time factors, and furthermore, their dose-response curves are in general steeper than for tumours. Hence, care should be taken in accelerating treatments to improve local control, if the treatments are truly at tolerance regarding late-appearing major complications.
CitationTreatment acceleration in radiotherapy: the relative time factors and dose-response slopes for tumours and normal tissues. 1992, 25 (4):308-12 Radiother Oncol
JournalRadiotherapy and Oncology