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Detection of EBV DNA in post-nasal space biopsy tissue from asymptomatic EBV-seropositive individuals.

dc.contributor.authorLees, Janice F
dc.contributor.authorGoodeve, A C
dc.contributor.authorArrand, J E
dc.contributor.authorGhosh, Anna K
dc.contributor.authorJones, P H
dc.contributor.authorArrand, John R
dc.date.accessioned2010-08-03T08:43:43Z
dc.date.available2010-08-03T08:43:43Z
dc.date.issued1992-05
dc.identifier.citationDetection of EBV DNA in post-nasal space biopsy tissue from asymptomatic EBV-seropositive individuals. 1992, 37 (1):30-8 J. Med. Virol.en
dc.identifier.issn0146-6615
dc.identifier.pmid1320096
dc.identifier.doi10.1002/jmv.1890370106
dc.identifier.urihttp://hdl.handle.net/10541/108884
dc.description.abstractThe association between EBV and nasopharyngeal carcinoma (NPC) has been well documented although the precise role of the virus in the genesis of the tumour is not understood. We undertook this study to examine the prevalence of EBV infection in nasopharyngeal tissue obtained from 33 healthy individuals not considered to be at risk of developing NPC. Using polymerase chain amplification (PCR) and in situ hybridization we have identified EBV DNA in 70% (23/33) of the tissues examined. Our data demonstrate that EBV is present at the site of tumour development in the low-risk population and by inference that the virus is also present before the onset of disease in the high-risk group. This survey supports the concept of NPC pathogenesis as a multifactorial process.
dc.language.isoenen
dc.subjectNasopharyngeal Canceren
dc.subjectTumour Virus Infectionsen
dc.subject.meshBase Sequence
dc.subject.meshBiopsy
dc.subject.meshDNA, Viral
dc.subject.meshFemale
dc.subject.meshHerpesvirus 4, Human
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMale
dc.subject.meshMolecular Sequence Data
dc.subject.meshNasal Cavity
dc.subject.meshNasopharyngeal Neoplasms
dc.subject.meshNucleic Acid Hybridization
dc.subject.meshPolymerase Chain Reaction
dc.subject.meshSensitivity and Specificity
dc.subject.meshTumor Virus Infections
dc.titleDetection of EBV DNA in post-nasal space biopsy tissue from asymptomatic EBV-seropositive individuals.en
dc.typeArticleen
dc.contributor.departmentPaterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.en
dc.identifier.journalJournal of Medical Virologyen
html.description.abstractThe association between EBV and nasopharyngeal carcinoma (NPC) has been well documented although the precise role of the virus in the genesis of the tumour is not understood. We undertook this study to examine the prevalence of EBV infection in nasopharyngeal tissue obtained from 33 healthy individuals not considered to be at risk of developing NPC. Using polymerase chain amplification (PCR) and in situ hybridization we have identified EBV DNA in 70% (23/33) of the tissues examined. Our data demonstrate that EBV is present at the site of tumour development in the low-risk population and by inference that the virus is also present before the onset of disease in the high-risk group. This survey supports the concept of NPC pathogenesis as a multifactorial process.


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