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    K-ras gene mutations in adenomas and carcinomas of the colon.

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    Authors
    Boughdady, I S
    Kinsella, Anne R
    Haboubi, N Y
    Schofield, Philip F
    Affiliation
    Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
    Issue Date
    1992-08
    
    Metadata
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    Abstract
    DNA extracted from 29 colorectal carcinomas and 40 sporadic adenomas was amplified by the polymerase chain reaction (PCR) and analysed for the presence of K-ras gene mutations at codon 12 using a panel of synthetic oligonucleotide probes specific for normal and mutated sequences. The presence of mutations was correlated with various histopathological and clinical data. Ten carcinomas (34.5%) and 14 sporadic adenomas (35%) showed K-ras mutations at codon 12. In the carcinoma group, no apparent correlation was found between the presence of mutant oncogenes and the degree of histological differentiation, Dukes' staging or the development of distant metastasis. In the adenoma group, the frequency of mutations increased with the size of the adenoma and the severity of the dysplastic changes. This study confirms that ras gene mutations are common and early events in colon carcinogenesis. They appear to give a selective growth advantage to those polyps with mutations which leads to their increase in size and thus possibly prepare the ground for malignant transformation.
    Citation
    K-ras gene mutations in adenomas and carcinomas of the colon. 1992, 1 (4):275-82 Surg Oncol
    Journal
    Surgical Oncology
    URI
    http://hdl.handle.net/10541/108877
    DOI
    10.1016/0960-7404(92)90088-3
    PubMed ID
    1341261
    Type
    Article
    Language
    en
    ISSN
    0960-7404
    ae974a485f413a2113503eed53cd6c53
    10.1016/0960-7404(92)90088-3
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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