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    K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients.

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    Authors
    Boughdady, I S
    Kinsella, Anne R
    Haboubi, N Y
    Schofield, Philip F
    Affiliation
    Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
    Issue Date
    1992-08
    
    Metadata
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    Abstract
    Colorectal adenomas and carcinomas from familial adenomatous polyposis (FAP) patients were screened for the presence of K-ras gene mutations at codon 12 using an in vitro amplification step (polymerase chain reaction) followed by dot blot analysis using oligonucleotide probes specific for different mutations at codon 12. We examined 28 colorectal adenomas and two colorectal carcinomas from 12 FAP patients and observed a mutation at codon 12 in seven adenomas and in both carcinomas. The frequency of K-ras gene mutations in colorectal tumours from FAP patients is similar to those in cases of sporadic adenomas and sporadic colorectal carcinomas indicating that the mechanisms involved in their development may be similar.
    Citation
    K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients. 1992, 1 (4):269-74 Surg Oncol
    Journal
    Surgical Oncology
    URI
    http://hdl.handle.net/10541/108876
    DOI
    10.1016/0960-7404(92)90087-2
    PubMed ID
    1341260
    Type
    Article
    Language
    en
    ISSN
    0960-7404
    ae974a485f413a2113503eed53cd6c53
    10.1016/0960-7404(92)90087-2
    Scopus Count
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    All Paterson Institute for Cancer Research

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