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dc.contributor.authorCowling, Graham J
dc.contributor.authorDexter, T Michael
dc.date.accessioned2010-08-03T08:20:36Z
dc.date.available2010-08-03T08:20:36Z
dc.date.issued1992-10
dc.identifier.citationErythropoietin and myeloid colony stimulating factors. 1992, 10 (10):349-57 Trends Biotechnol.en
dc.identifier.issn0167-7799
dc.identifier.pmid1368874
dc.identifier.doi10.1016/0167-7799(92)90267-Y
dc.identifier.urihttp://hdl.handle.net/10541/108875
dc.description.abstractThe production of blood cells in the body is controlled by at least 20 polypeptide growth factors. Most of these factors have been cloned and many expressed in bacterial and eukaryotic systems to give biologically active proteins. Currently, these recombinant human proteins are undergoing intensive evaluation for their use in treating primary haemopoietic diseases, or stimulating normal haemopoiesis following drug-, radiation- or virus-induced trauma of the bone marrow. Erythropoietin (EPO) and the myeloid colony stimulating factors (IL-3, G-CSF, GM-CSF and M-CSF) were among the first to be cloned and expressed.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCloning, Molecular
dc.subject.meshColony-Stimulating Factors
dc.subject.meshErythropoietin
dc.subject.meshGlycosylation
dc.subject.meshHumans
dc.subject.meshProtein Conformation
dc.subject.meshStructure-Activity Relationship
dc.titleErythropoietin and myeloid colony stimulating factors.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalTrends in Biotechnologyen
html.description.abstractThe production of blood cells in the body is controlled by at least 20 polypeptide growth factors. Most of these factors have been cloned and many expressed in bacterial and eukaryotic systems to give biologically active proteins. Currently, these recombinant human proteins are undergoing intensive evaluation for their use in treating primary haemopoietic diseases, or stimulating normal haemopoiesis following drug-, radiation- or virus-induced trauma of the bone marrow. Erythropoietin (EPO) and the myeloid colony stimulating factors (IL-3, G-CSF, GM-CSF and M-CSF) were among the first to be cloned and expressed.


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