Affiliation
CRC Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.Issue Date
1992-10
Metadata
Show full item recordAbstract
The production of blood cells in the body is controlled by at least 20 polypeptide growth factors. Most of these factors have been cloned and many expressed in bacterial and eukaryotic systems to give biologically active proteins. Currently, these recombinant human proteins are undergoing intensive evaluation for their use in treating primary haemopoietic diseases, or stimulating normal haemopoiesis following drug-, radiation- or virus-induced trauma of the bone marrow. Erythropoietin (EPO) and the myeloid colony stimulating factors (IL-3, G-CSF, GM-CSF and M-CSF) were among the first to be cloned and expressed.Citation
Erythropoietin and myeloid colony stimulating factors. 1992, 10 (10):349-57 Trends Biotechnol.Journal
Trends in BiotechnologyDOI
10.1016/0167-7799(92)90267-YPubMed ID
1368874Type
ArticleLanguage
enISSN
0167-7799ae974a485f413a2113503eed53cd6c53
10.1016/0167-7799(92)90267-Y