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Nitrogen analogues of haematoporphyrin and haematoporphyrin derivative.

dc.contributor.authorForbes, E
dc.contributor.authorKeir, W F
dc.contributor.authorMacLennan, A H
dc.contributor.authorMoore, James V
dc.contributor.authorTruscott, T G
dc.date.accessioned2010-08-02T16:23:00Z
dc.date.available2010-08-02T16:23:00Z
dc.date.issued1992-12-24
dc.identifier.citationNitrogen analogues of haematoporphyrin and haematoporphyrin derivative. 1992, 67 (2-3):175-85 Cancer Lett.en
dc.identifier.issn0304-3835
dc.identifier.pmid1483265
dc.identifier.doi10.1016/0304-3835(92)90141-H
dc.identifier.urihttp://hdl.handle.net/10541/108843
dc.description.abstractThe preparation of a number of amines related to haematoporphyrin (HP) and haematoporphyrin derivative (HPD) have been studied and their composition and structure discussed through examination of their 1H, 13C NMR and mass spectral data and other physical properties. In vitro biological studies have been carried out and have shown these amines to have a similar photodynamic efficiency to that of HPD. One of these showed cytotoxic properties at exceptionally low light energy levels.
dc.language.isoenen
dc.subjectHaematoporphyrin Derivativeen
dc.subjectHaematoporphyrin Photoradiationen
dc.subjectHaematoporphyrinsen
dc.subjectCanceren
dc.subjectCultured Tumour Cellsen
dc.subject.meshCell Survival
dc.subject.meshHematoporphyrin Derivative
dc.subject.meshHematoporphyrin Photoradiation
dc.subject.meshHematoporphyrins
dc.subject.meshHumans
dc.subject.meshMolecular Structure
dc.subject.meshNeoplasms
dc.subject.meshNitrogen
dc.subject.meshStructure-Activity Relationship
dc.subject.meshTumor Cells, Cultured
dc.titleNitrogen analogues of haematoporphyrin and haematoporphyrin derivative.en
dc.typeArticleen
dc.contributor.departmentDepartment of Chemistry and Chemical Engineering, University of Paisley, Renfrewshire, Scotland, UK.en
dc.identifier.journalCancer Lettersen
html.description.abstractThe preparation of a number of amines related to haematoporphyrin (HP) and haematoporphyrin derivative (HPD) have been studied and their composition and structure discussed through examination of their 1H, 13C NMR and mass spectral data and other physical properties. In vitro biological studies have been carried out and have shown these amines to have a similar photodynamic efficiency to that of HPD. One of these showed cytotoxic properties at exceptionally low light energy levels.


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